Department of Clinical Research Coordination, National Center for Global Health and Medicine, Tokyo, Japan.
Obesity (Silver Spring). 2012 Aug;20(8):1744-9. doi: 10.1038/oby.2011.285. Epub 2011 Oct 13.
The relationships between metabolic risk factors and abdominal fat distribution determined using computed tomography (CT) are poorly defined in large populations. We investigated the cutoff values of the visceral fat area (VFA) to detect subjects with multiple risk factors of metabolic syndrome (MS) by sex and age groups, and attempted to examine whether sex- and age-specific cutoff values are needed. The subjects of this study were 11,561 Japanese men and women who participated in the Hitachi Health Study, received CT examination, and answered questionnaires on lifestyles between 2004 and 2009. VFA and waist circumference were measured using CT. The VFA cutoff values yielding an 80% sensitivity for the detection of multiple risk factors of MS were typically smaller among men under the age of 40 years (<40 years vs. ≥40 years; 86.4 cm(2) vs. 103.9 cm(2)). The area under the receiver operator characteristic curve of VFA for the detection tended to decrease according to age (P = 0.056 and P = 0.020 for trends in men and women). Age- and sex-specific cutoff values are needed. The sensitivity of the subjects under the age of 40 years is relatively smaller (70.0% for men and 60.0% for women) compare to other age groups when the same cutoff value is used regardless of age (e.g., cutoff value calculated to correspond to 80% sensitivity for subjects of all ages). Therefore, a smaller VFA cutoff point should be used among men under the age of 40 years.
在大型人群中，使用计算机断层扫描 (CT) 确定的代谢危险因素与腹部脂肪分布之间的关系定义不明确。我们研究了内脏脂肪面积 (VFA) 的截止值，以按性别和年龄组检测代谢综合征 (MS) 的多种危险因素，同时尝试检查是否需要特定于性别和年龄的截止值。本研究的对象是 11561 名日本男性和女性，他们参加了日立健康研究，在 2004 年至 2009 年期间接受了 CT 检查，并回答了关于生活方式的问卷。使用 CT 测量了 VFA 和腰围。VFA 截止值的敏感性通常在 40 岁以下的男性中更高（<40 岁与≥40 岁；86.4cm²与 103.9cm²），用于检测 MS 的多种危险因素。VFA 用于检测的受试者的曲线下面积倾向于随着年龄的增加而降低（男性和女性的趋势 P=0.056 和 P=0.020）。需要年龄和性别特异性的截止值。无论年龄如何，使用相同的截止值（例如，计算出适用于所有年龄组的受试者 80%敏感性的截止值），40 岁以下的受试者的敏感性相对较小（男性为 70.0%，女性为 60.0%）。因此，40 岁以下的男性应该使用更小的 VFA 截止点。
