Catholic University of America, Washington, District of Columbia 20064, USA.
J Biomed Opt. 2012 Jul;17(7):076014. doi: 10.1117/1.JBO.17.7.076014.
Optimal treatment of skin cancer before it metastasizes critically depends on early diagnosis and treatment. Imaging spectroscopy and polarized remittance have been utilized in the past for diagnostic purposes, but valuable information can be also obtained from the analysis of skin roughness. For this purpose, we have developed an out-of-plane hemispherical Stokes imaging polarimeter designed to monitor potential skin neoplasia based on a roughness assessment of the epidermis. The system was utilized to study the rough surface scattering for wax samples and human skin. The scattering by rough skin-simulating phantoms showed behavior that is reasonably described by a facet scattering model. Clinical tests were conducted on patients grouped as follows: benign nevi, melanocytic nevus, melanoma, and normal skin. Images were captured and analyzed, and polarization properties are presented in terms of the principal angle of the polarization ellipse and the degree of polarization. In the former case, there is separation between different groups of patients for some incidence azimuth angles. In the latter, separation between different skin samples for various incidence azimuth angles is observed.
在皮肤癌转移之前进行最佳治疗，关键取决于早期诊断和治疗。过去已经利用成像光谱学和偏振反射来进行诊断，但也可以从皮肤粗糙度分析中获得有价值的信息。为此，我们开发了一种非平面半球斯托克斯成像偏振计，旨在根据表皮粗糙度评估来监测潜在的皮肤肿瘤。该系统用于研究蜡样和人体皮肤的粗糙表面散射。粗糙皮肤模拟体的散射行为可以通过面散射模型合理地描述。对以下分组的患者进行了临床测试：良性痣、黑素细胞痣、黑色素瘤和正常皮肤。拍摄和分析了图像，并以偏振椭圆的主角和偏振度的形式呈现了偏振特性。在前一种情况下，对于某些入射方位角，不同组的患者之间存在分离。在后一种情况下，对于不同的入射方位角，不同的皮肤样本之间存在分离。
