Morgan Kaye S, Paganin David M, Siu Karen K W
School of Physics, Monash University, Clayton, VIC, 3800, Australia.
Opt Express. 2011 Sep 26;19(20):19781-9. doi: 10.1364/OE.19.019781.
A single-exposure quantitative method of x-ray phase contrast imaging, suitable for animal in vivo observations, is described and shown experimentally both for a known static sample and an ex vivo biological airway. The ability to acquire the desired information within a single exposure is important for dynamic samples, as is sufficient sensitivity to reveal small variations in the composition or thickness of such a sample. This approach satisfies both these needs by analyzing how a reference grid pattern is deformed by the presence of the sample, similar to a Shack-Hartmann sensor. By resolving the shift of the pattern into horizontal and vertical components, a quantitative phase depth map is recovered, sensitive to both sharp edges as well as low phase gradients.
描述了一种适用于动物体内观察的X射线相衬成像单曝光定量方法，并通过实验展示了该方法用于已知静态样品和离体生物气道的情况。对于动态样品而言，在单次曝光内获取所需信息的能力很重要，对于揭示此类样品的组成或厚度的微小变化而言，足够的灵敏度也很重要。这种方法通过分析参考网格图案如何因样品的存在而变形来满足这两个需求，这类似于夏克-哈特曼传感器。通过将图案的偏移分解为水平和垂直分量，可以恢复对尖锐边缘以及低相位梯度均敏感的定量相深度图。
