自噬与 p62 在心脏蛋白质量控制中的作用
Autophagy and p62 in cardiac protein quality control.
机构信息
Protein Quality Control and Degradation Research Center, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.
出版信息
Autophagy. 2011 Nov;7(11):1382-3. doi: 10.4161/auto.7.11.17339. Epub 2011 Nov 1.
Abstract
This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.
摘要
这是最近一份报告的增刊，首次证明自噬通量在心脏蛋白病的既定小鼠模型中增加，并且 p62 在过度表达人类心肌病相关错误折叠蛋白的心肌细胞和心脏中转录上调。在过度表达错误折叠蛋白的心肌细胞中，p62 在包含蛋白聚集体的小体形成和自噬激活中发挥关键和保护作用。
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本文引用的文献
1
Autophagy and p62 in cardiac proteinopathy.自噬和 p62 在心脏蛋白病变中的作用。
Circ Res. 2011 Jul 22;109(3):296-308. doi: 10.1161/CIRCRESAHA.111.244707. Epub 2011 Jun 9.
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