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[氯化钡在鼠伤寒沙门氏菌中的诱变活性]

[Mutagen activity of barium chloride in Salmonella typhimurium].

作者信息

Monaco M, Dominici R, Barisano P, Di Palermo G

机构信息

Centro Studi di Medicina dei Trasporti, Ente Ferrovie dello Stato, Roma.

出版信息

Med Lav. 1990 Jan-Feb;81(1):54-64.

PMID:2199807
Abstract

Barium chloride, which is an important industrial chemical used in pigments, lacquers, dyes, glass and pesticide production, leather tanning and cloth dying, was tested on Salmonella typhimurium (TA 1535, TA 1537, TA 1538, TA 97, TA 98, TA 100) with the reverse mutation test, with and without metabolic activation, to assess its possible genotoxic effects and any possible action with respect to standard mutagens (sodium azide, 9-aminoacridine, 2-nitrofluorene, mitomycine-C, 2 aminoacridine). Using the platelet incorporation technique, barium chloride at various progressive concentrations gave negative results under the experimental conditions of the study.

摘要

氯化钡是一种重要的工业化学品,用于颜料、漆、染料、玻璃和农药生产、皮革鞣制及布料染色。采用回复突变试验,在有和没有代谢活化的情况下,对鼠伤寒沙门氏菌(TA 1535、TA 1537、TA 1538、TA 97、TA 98、TA 100)进行了测试,以评估其可能的遗传毒性效应以及对标准诱变剂(叠氮化钠、9-氨基吖啶、2-硝基芴、丝裂霉素-C、2-氨基吖啶)的任何可能作用。在该研究的实验条件下,采用血小板掺入技术,不同递增浓度的氯化钡均给出阴性结果。

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