Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Soochow, China.
Macromol Biosci. 2012 Jan;12(1):126-31. doi: 10.1002/mabi.201100211. Epub 2011 Oct 13.
Surfaces with resistance to non-specific protein adsorption and a high capacity to bind plasminogen from plasma are developed for application as fibrinolytic surfaces in blood contact. A new method is reported for grafting poly(OEGMA-co-HEMA) copolymers on polyurethane surfaces. The OEGMA provides effective protein resistance due to the PEG side chains and the HEMA provides a high density of OH groups for attachment of lysine. Adsorption of fibrinogen from buffer and plasma to these surfaces is low, indicating significant protein resistance. Plasminogen binding from plasma is high, and clot dissolution on surfaces where plasminogen adsorbed from plasma is converted to plasmin is rapid.
用于血液接触的抗非特异性蛋白质吸附和高血浆纤溶酶原结合能力的表面被开发出来用于作为纤维蛋白溶酶表面。本文报道了一种在聚氨酯表面接枝聚（OEGMA-co-HEMA）共聚物的新方法。由于 PEG 侧链，OEGMA 提供了有效的蛋白质抗性，而 HEMA 则提供了高密度的 OH 基团用于赖氨酸的附着。从缓冲液和血浆中吸附到这些表面的纤维蛋白原较少，表明具有显著的蛋白质抗性。从血浆中吸附的纤溶酶原结合量高，并且在将从血浆中吸附的纤溶酶原转化为纤溶酶的表面上，血栓溶解迅速。
