Drobota Mioara, Ursache Stefan, Aflori Magdalena
"Petru Poni" Institute of Macromolecular Chemistry, 41A Aleea Gr. Ghica Voda, 700487 Iasi, Romania.
Innovative Green Power, No. 5 Iancu Bacalu Street, 700029 Iasi, Romania.
Polymers (Basel). 2022 Jun 7;14(12):2307. doi: 10.3390/polym14122307.
Changes of a material biointerface allow for specialized cell signaling and diverse biological responses. Biomaterials incorporating immobilized bioactive ligands have been widely introduced and used for tissue engineering and regenerative medicine applications in order to develop biomaterials with improved functionality. Furthermore, a variety of physical and chemical techniques have been utilized to improve biomaterial functionality, particularly at the material interface. At the interface level, the interactions between materials and cells are described. The importance of surface features in cell function is then examined, with new strategies for surface modification being highlighted in detail.
材料生物界面的变化允许特定的细胞信号传导和多样的生物学反应。为了开发具有改进功能的生物材料，结合固定化生物活性配体的生物材料已被广泛引入并用于组织工程和再生医学应用。此外，已经利用了各种物理和化学技术来改善生物材料的功能，特别是在材料界面处。在界面层面，描述了材料与细胞之间的相互作用。然后研究了表面特征在细胞功能中的重要性，并详细强调了表面修饰的新策略。
