Pacelli Settimio, Manoharan Vijayan, Desalvo Anna, Lomis Nikita, Jodha Kartikeya Singh, Prakash Satya, Paul Arghya
BioIntel Research Laboratory, Department of Chemical and Petroleum Engineering, Bioengineering Graduate Program, School of Engineering, University of Kansas, Lawrence, KS, USA.
University of Southampton, School of Medicine, University Road, Southampton SO17 1BJ, United Kingdom.
J Mater Chem B. 2016;4:1586-1599. doi: 10.1039/C5TB01686J. Epub 2015 Oct 16.
Host body response to a foreign medical device plays a critical role in defining its fate post implantation. It is thus important to control host-material interactions by designing innovative implant surfaces. In the recent years, biochemical and topographical features have been explored as main target to produce this new type of bioinert or bioresponsive implants. The review discusses specific biofunctional materials and strategies to achieve a precise control over implant surface properties and presents possible solutions to develop next generation of implants, particularly in the fields of bone and cardiovascular therapy.
宿主身体对外部医疗设备的反应在决定其植入后的命运方面起着关键作用。因此，通过设计创新的植入物表面来控制宿主与材料之间的相互作用非常重要。近年来，生物化学和拓扑学特征已被探索为制造这种新型生物惰性或生物反应性植入物的主要目标。本文综述讨论了用于精确控制植入物表面特性的特定生物功能材料和策略，并提出了开发下一代植入物的可能解决方案，特别是在骨治疗和心血管治疗领域。
