Department of Surgery, University of Luebeck, Medical School, Ratzeburger Allee 160, D-23538 Luebeck, Germany.
Expert Rev Anticancer Ther. 2011 Oct;11(10):1567-75. doi: 10.1586/era.11.123.
The incidence of colorectal cancers is rising worldwide and pulmonary metastases were seen in approximately 10-15% of all patients. Surgical metastasectomy is a widely accepted procedure in selected patients and is considered as the only curative option in patients with secondary pulmonary malignancy. But surgical resection remains controversial due to the lack of randomized trials, comparing pulmonary metastasectomy to control, either medical therapy, or observation. This article will discuss the differentiated therapeutic strategies for patients with pulmonary metastases of colorectal cancer, focusing on surgical resection, patient evaluation, prognostic factors, interdisciplinary therapeutic approaches and current trials.
结直肠癌的发病率在全球范围内呈上升趋势，约 10-15%的患者出现肺部转移。在选择的患者中，外科转移灶切除术是一种广泛接受的治疗方法，被认为是继发性肺部恶性肿瘤患者唯一的治愈方法。但由于缺乏随机对照试验，将肺转移灶切除术与对照（包括药物治疗或观察）进行比较，因此手术切除仍然存在争议。本文将讨论结直肠癌肺转移患者的差异化治疗策略，重点介绍手术切除、患者评估、预后因素、跨学科治疗方法和目前的临床试验。
