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Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial.regorafenib 单药治疗既往治疗的转移性结直肠癌（CORRECT）：一项国际、多中心、随机、安慰剂对照、3 期临床试验。
Lancet. 2013 Jan 26;381(9863):303-12. doi: 10.1016/S0140-6736(12)61900-X. Epub 2012 Nov 22.
2
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial.贝伐珠单抗治疗转移性结直肠癌（ML18147）一线进展后的延续治疗：一项随机 3 期临床试验
Lancet Oncol. 2013 Jan;14(1):29-37. doi: 10.1016/S1470-2045(12)70477-1. Epub 2012 Nov 16.
3
ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making.ESMO 结肠癌和直肠癌患者管理共识指南。 个体化临床决策方法。
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4
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J Clin Oncol. 2012 Oct 1;30(28):3499-506. doi: 10.1200/JCO.2012.42.8201. Epub 2012 Sep 4.
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Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial.西妥昔单抗联合奥沙利铂一线治疗晚期结直肠癌的随机 3 期 MRC COIN 试验结果。
Lancet. 2011 Jun 18;377(9783):2103-14. doi: 10.1016/S0140-6736(11)60613-2. Epub 2011 Jun 5.

影响转移性结直肠癌（mCRC）化疗方案选择的因素。

Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC).

作者信息

Rossi Luigi, Vakiarou Foteini, Zoratto Federica, Bianchi Loredana, Papa Anselmo, Basso Enrico, Verrico Monica, Lo Russo Giuseppe, Evangelista Salvatore, Rinaldi Guilia, Perrone-Congedi Francesca, Spinelli Gian Paolo, Stati Valeria, Caruso Davide, Prete Alessandra, Tomao Silverio

机构信息

Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.

出版信息

Cancer Manag Res. 2013 Nov 19;5:377-85. doi: 10.2147/CMAR.S47986.

DOI:10.2147/CMAR.S47986
PMID:24399885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3875371/
Abstract

Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.

摘要

转移性结直肠癌的管理需要多模式方法，并且必须由经验丰富的多学科专家团队来实施。根据疾病的定位和范围、肿瘤生物学特性以及患者的临床特征，选择最佳的个体化治疗方式，应是能够维持生活质量和长期生存，甚至治愈部分患者的方法。本综述概述了转移性结直肠癌可用的不同治疗方法，目的是根据肿瘤生物学特性和患者临床特征确定个性化治疗方案。