Kenyon Christine L, Basaraba Randall J, Bohn Andrea A
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA.
J Am Vet Med Assoc. 2011 Nov 1;239(9):1201-10. doi: 10.2460/javma.239.9.1201.
To determine effects of long-distance racing exercise on iron status in endurance racing sled dogs, with or without anemia.
Prospective cohort study.
114 dogs that participated in the 2007 Iditarod Trail Sled Dog Race (59 and 55 dogs that did or did not complete the race, respectively).
Stored serum samples obtained from 85 endurance-racing sled dogs that were expected to participate in the race were used to establish study reference intervals and prerace group values for iron-related variables. Blood samples collected from 114 study dogs before (ie, baseline) and after participation in the race were used to determine PCV and serum total protein concentrations before and after racing and assess iron-related variables after racing.
Mean values for PCV and serum total protein concentration were decreased after racing, compared with baseline values in the same dogs. Mean serum iron concentration was low, and mean serum ceruloplasmin and C-reactive protein (CRP) concentrations were high in dogs after racing, compared with prerace group values. Mean serum ferritin concentration was high in dogs that did not complete the race, compared with the prerace group value and that of dogs that finished the race; 4 of 113 (3.5%) study dogs had low ferritin concentrations (< 73 ng/mL) after racing, suggestive of possible iron deficiency.
Decreased PCV and serum total protein concentrations were consistently detected, whereas iron deficiency appeared to be uncommon, in study dogs after race participation. High serum concentrations of ceruloplasmin and CRP after racing suggested that changes indicative of iron deficiency may be masked by inflammation. Alternatively, changes in serum iron and CRP concentrations may reflect a physiologic response.
确定长跑运动对耐力赛雪橇犬铁状态的影响，无论其是否患有贫血。
前瞻性队列研究。
114只参加2007年艾迪塔罗德小道雪橇犬比赛的犬（分别有59只和55只完成或未完成比赛）。
从预计参加比赛的85只耐力赛雪橇犬中获取储存的血清样本，用于建立铁相关变量的研究参考区间和赛前组值。从114只研究犬在比赛前（即基线）和比赛后采集的血样，用于测定比赛前后的红细胞压积和血清总蛋白浓度，并评估比赛后的铁相关变量。
与同一只犬的基线值相比，比赛后红细胞压积和血清总蛋白浓度的平均值降低。与赛前组值相比，比赛后犬的血清铁浓度平均值较低，血清铜蓝蛋白和C反应蛋白（CRP）浓度平均值较高。与赛前组值和完成比赛的犬相比，未完成比赛的犬血清铁蛋白浓度平均值较高；113只研究犬中有4只（3.5%）在比赛后铁蛋白浓度较低（<73 ng/mL），提示可能存在缺铁。
在参与比赛的研究犬中，持续检测到红细胞压积和血清总蛋白浓度降低，而缺铁似乎并不常见。比赛后血清铜蓝蛋白和CRP浓度升高表明，缺铁的指示性变化可能被炎症掩盖。或者，血清铁和CRP浓度的变化可能反映了一种生理反应。
