Burr J R, Reinhart G A, Swenson R A, Swaim S E, Vaughn D M, Bradley D M
Research and Development Division, Lams Co, Lewisburg, OH 45338, USA.
J Am Vet Med Assoc. 1997 Jul 15;211(2):175-9.
To measure and compare blood values in sled dogs before and after long-distance racing.
Prospective study.
17 adult sled dogs in the 1991 Iditarod Trail Sled Dog Race and 21 in a simulated sled dog race.
Blood samples were obtained from 17 dogs 7 days before they began and after they finished (finisher group) or were eliminated from (nonfinisher group) the Iditarod Trail Sled Dog Race. Blood samples were also obtained from 21 dogs before and after a simulated sled dog race.
In finisher-group dogs, BUN and uric acid (UA) concentrations were increased after racing; nonfinisher-group dogs had significantly lower postrace BUN and UA concentrations. Significant increases in creatine kinase (CK) and aspartate transferase (AST) activities were detected in all dogs after racing, and postrace values were higher in nonfinisher-group dogs, compared with finisher-group dogs. Mean alkaline phosphate activities were significantly increased after racing in nonfinisher-group dogs only. In dogs that ran the simulated race, postrace values for serum albumin, total protein, calcium, and potassium concentrations, as well as Hct, hemoglobin concentration, and RBC count, were significantly lower than prerace values. Postrace values for alkaline phosphate, alanine transaminase, AST, lactate dehydrogenase, CK, BUN, and UA were significantly higher than prerace values.
High CK activities are indicative of severe muscle degeneration and, in sled dogs, may represent a degree of muscle breakdown beyond which a dog cannot continue to work. Markedly high CK, and possibly AST, serum activities may be indicators of performance failure in sled dogs competing in long-distance races.
测量并比较雪橇犬在长距离比赛前后的血液指标。
前瞻性研究。
1991年艾迪塔罗德小道雪橇犬比赛中的17只成年雪橇犬以及21只参加模拟雪橇犬比赛的雪橇犬。
在17只参加艾迪塔罗德小道雪橇犬比赛的犬开始比赛前7天、比赛结束后（完成比赛组）或被淘汰后（未完成比赛组）采集血样。也在21只参加模拟雪橇犬比赛的犬比赛前后采集血样。
在完成比赛组的犬中，比赛后血尿素氮（BUN）和尿酸（UA）浓度升高；未完成比赛组的犬赛后BUN和UA浓度显著较低。所有犬在比赛后肌酸激酶（CK）和天冬氨酸转氨酶（AST）活性均显著升高，与完成比赛组的犬相比，未完成比赛组的犬赛后值更高。仅未完成比赛组的犬在比赛后平均碱性磷酸酶活性显著升高。在参加模拟比赛的犬中，赛后血清白蛋白、总蛋白、钙和钾浓度以及血细胞比容、血红蛋白浓度和红细胞计数的值均显著低于赛前值。赛后碱性磷酸酶、丙氨酸转氨酶、AST、乳酸脱氢酶、CK、BUN和UA的值均显著高于赛前值。
高CK活性表明严重的肌肉变性，在雪橇犬中，可能代表一定程度的肌肉损伤，超过此程度犬就无法继续工作。明显升高的CK以及可能还有AST的血清活性可能是参加长距离比赛的雪橇犬表现不佳的指标。
