Spoo J W, Downey R L, Griffitts C, Horst R J, Levine C B, Childs R M, Wakshlag J J
Best Care Pet Hospital, Sioux Falls, SD.
J Vet Intern Med. 2015 Mar-Apr;29(2):519-25. doi: 10.1111/jvim.12546.
Dogs are a unique model for examining the effects of exercise on vitamin D status because of their lack of vitamin D synthesis by UV exposure. In addition, the inflammatory response may be associated with hypovitaminosis D.
To investigate the effects of several days of endurance exercise on plasma vitamin D (25-(OH)D3, 24,25-(OH)D3 and 1,25(OH)D3) and serum C-reactive protein (CRP) concentrations in stage-stop racing sled dogs.
12 racing sled dogs and 8 control dogs.
Blood was collected before the race and immediately after racing on days 2 and 8. Plasma vitamin D metabolites and serum CRP concentrations were measured.
Racing dogs showed a significant increase in 25(OH)D3 on day 2 (P = .027) and day 8 of the race (P < .001), whereas no increases were observed in control dogs. The plasma concentration of 24,25(OH)D3 showed a significant increase by day 8 (P < .001). There were no significant changes in 1,25(OH) D3 concentrations across all time points and groups. Racing dogs had significantly increased CRP concentrations by day 2 (39.3 ± 30.1 μg/mL; P < .001).
Increases in vitamin D metabolites as well as increases in CRP concentrations were observed in racing sled dogs. This finding was contrary to the hypothesis that decreases in vitamin D status in athletes may be related to the acute phase inflammatory response during exercise. In addition, the increased 24,25(OH)D3 concentrations compared to what is observed in other species suggests metabolic variations in dogs that lead to enhanced disposal of vitamin D.
由于狗缺乏通过紫外线照射合成维生素D的能力，它们是研究运动对维生素D状态影响的独特模型。此外，炎症反应可能与维生素D缺乏症有关。
研究多日耐力运动对赛段终点竞速雪橇犬血浆维生素D（25-（OH）D3、24,25-（OH）D3和1,25（OH）D3）和血清C反应蛋白（CRP）浓度的影响。
12只竞速雪橇犬和8只对照犬。
在比赛前以及比赛第2天和第8天结束后立即采集血液。测量血浆维生素D代谢物和血清CRP浓度。
比赛犬在比赛第2天（P = 0.027）和第8天（P < 0.001）时25（OH）D3显著增加，而对照犬未观察到增加。到第8天，24,25（OH）D3的血浆浓度显著增加（P < 0.001）。在所有时间点和组中，1,25（OH）D3浓度均无显著变化。比赛犬在第2天时CRP浓度显著增加（39.3 ± 30.1 μg/mL；P < 0.001）。
在竞速雪橇犬中观察到维生素D代谢物增加以及CRP浓度增加。这一发现与运动员维生素D状态下降可能与运动期间的急性期炎症反应有关的假设相反。此外，与其他物种相比，24,25（OH）D3浓度增加表明狗存在代谢差异，导致维生素D的处置增强。
