Clementz B A, Sweeney J A
Laboratory of Clinical Psychophysiology, New York Hospital-Cornell Medical Center.
Psychol Bull. 1990 Jul;108(1):77-92. doi: 10.1037/0033-2909.108.1.77.
There is a high prevalence of eye movement dysfunction (EMD) in persons with schizophrenia and their first-degree relatives. Studies addressing the prevalence, stability, familial transmission, and psychological correlates of EMD in persons from both psychiatric and general populations offer suggestive evidence that this abnormality may serve as a biological marker for schizophrenia. Although these findings are promising, their significance for elucidating the diagnostic bandwidth, pathophysiology, and genetics of this disorder remains to be determined. More precise characterization of ocular motility, perhaps when used in conjunction with global measures of pursuit adequacy, may be essential for clarifying the pathophysiological and genetic significance of EMD for schizophrenia. Recent research efforts are beginning to identify particular abnormalities that could serve as more specific biological markers for schizophrenia.
精神分裂症患者及其一级亲属中眼动功能障碍（EMD）的患病率很高。针对精神科和普通人群中EMD的患病率、稳定性、家族遗传以及心理相关性的研究提供了一些提示性证据，表明这种异常可能是精神分裂症的生物学标志物。尽管这些发现很有前景，但它们对于阐明该疾病的诊断范围、病理生理学和遗传学的意义仍有待确定。对眼球运动进行更精确的特征描述，或许与追踪充分性的整体测量相结合，可能对于阐明EMD对精神分裂症的病理生理学和遗传学意义至关重要。最近的研究工作开始识别出一些特定的异常情况，这些异常情况可能成为精神分裂症更具特异性的生物学标志物。
