Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
Curr Opin Neurobiol. 2012 Jun;22(3):470-9. doi: 10.1016/j.conb.2011.09.008. Epub 2011 Oct 14.
In the mammalian central nervous system, the majority of fast excitatory synaptic transmission is mediated by glutamate acting on AMPA-type ionotropic glutamate receptors. The abundance of AMPA receptors at the synapse can be modulated through receptor trafficking, which dynamically regulates many fundamental brain functions, including learning and memory. Reversible posttranslational modifications, including phosphorylation, palmitoylation and ubiquitination of AMPA receptor subunits are important regulatory mechanisms for controlling synaptic AMPA receptor expression and function. In this review, we highlight recent advances in the study of AMPA receptor posttranslational modifications and discuss how these modifications regulate AMPA receptor trafficking and function at synapses.
在哺乳动物中枢神经系统中，大多数快速兴奋性突触传递是由谷氨酸作用于 AMPA 型离子型谷氨酸受体介导的。突触处 AMPA 受体的丰度可以通过受体运输来调节，这可以动态调节许多基本的大脑功能，包括学习和记忆。AMPA 受体亚基的可逆翻译后修饰，包括磷酸化、棕榈酰化和泛素化，是控制突触 AMPA 受体表达和功能的重要调节机制。在这篇综述中，我们强调了 AMPA 受体翻译后修饰研究的最新进展，并讨论了这些修饰如何调节突触处的 AMPA 受体运输和功能。
