Greger Ingo H, Esteban José A
Neurobiology Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Curr Opin Neurobiol. 2007 Jun;17(3):289-97. doi: 10.1016/j.conb.2007.04.007. Epub 2007 May 1.
AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system. The trafficking of AMPA receptors to and from synapses alters synaptic strength and has been recognized as a central mechanism underlying various forms of synaptic plasticity. Both secretory and endocytic trafficking events seem to be driven by the subunit composition of AMPA receptor tetramers. Moreover, recent work suggests that synapses employ different tetramer combinations in response to altered synaptic input, suggesting the existence of signalling pathways that mediate remodelling of AMPA receptors. These latest developments and recent progress in elucidating the mechanisms that underlie channel assembly and trafficking are the subject of this review.
AMPA 型谷氨酸受体介导中枢神经系统中大部分快速兴奋性传递。AMPA 受体在突触间的转运改变了突触强度，并且已被认为是各种形式突触可塑性的核心机制。分泌性和内吞性转运事件似乎都由 AMPA 受体四聚体的亚基组成所驱动。此外，最近的研究表明，突触会根据改变的突触输入采用不同的四聚体组合，这表明存在介导 AMPA 受体重塑的信号通路。这些最新进展以及在阐明通道组装和转运基础机制方面的近期成果是本综述的主题。
