早期多发性硬化症中脑脊液富含高分化CD8 + T细胞。
CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis.
作者信息
Jilek Samantha, Schluep Myriam, Rossetti Andrea O, Guignard Laurence, Le Goff Géraldine, Pantaleo Giuseppe, Du Pasquier Renaud A
机构信息
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
出版信息
Clin Immunol. 2007 Apr;123(1):105-13. doi: 10.1016/j.clim.2006.11.004. Epub 2006 Dec 22.
CD8+ T cells may play an important role in multiple sclerosis (MS). Whether these cells would be involved in early stages of MS is unclear. We enrolled 52 patients with suspected MS, determined the recruitment of their highly differentiated (CCR7-/CD45RA+ or -) T cells (T(HD)) in the CSF as compared to peripheral blood and followed them for 12+/-7.3 months. A ROC curve showed that a CD8+/CD4+ T(HD) cells ratio of 0.94 helped to distinguish relapsing-remitting (RR-MS) and possible MS (Po-MS) from primary-progressive MS (PP-MS) and other neurological diseases patients (OND) patients (p=0.039), risk ratio of 2.29 (95% CI: 1.13-4.66; p=0.006). The CSF enrichment in CD8+ T(HD) cells was greater than in CD4+ T(HD) cells in RR/Po-MS patients (p=0.024) and than in CD8+ T(HD) cells in PP-MS/OND patients (p=0.006). These data suggest that CD8+ T(HD) cells play a role in the early stages of RR-MS.
CD8 + T细胞可能在多发性硬化症（MS）中发挥重要作用。这些细胞是否参与MS的早期阶段尚不清楚。我们招募了52例疑似MS患者，与外周血相比，测定其脑脊液中高分化（CCR7 - / CD45RA +或 - ）T细胞（T(HD)）的募集情况，并对他们进行了12±7.3个月的随访。ROC曲线显示，CD8 + / CD4 + T(HD)细胞比值为0.94有助于将复发缓解型（RR-MS）和可能的MS（Po-MS）与原发进展型MS（PP-MS）和其他神经系统疾病患者（OND）区分开来（p = 0.039），风险比为2.29（95% CI：1.13 - 4.66；p = 0.006）。RR/Po-MS患者脑脊液中CD8 + T(HD)细胞的富集程度高于CD4 + T(HD)细胞（p = 0.024），高于PP-MS/OND患者脑脊液中CD8 + T(HD)细胞的富集程度（p = 0.006）。这些数据表明，CD8 + T(HD)细胞在RR-MS的早期阶段发挥作用。
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