Zaima Kazumasa, Wakana Daigo, Demizu Yosuke, Kumeta Yukie, Kamakura Hiroyuki, Maruyama Takuro, Kurihara Masaaki, Goda Yukihiro
Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan.
J Nat Med. 2014 Apr;68(2):432-5. doi: 10.1007/s11418-013-0806-8. Epub 2013 Nov 7.
A new amino acid-sesquiterpene adduct, isoheleproline (1), was isolated from the roots of Inula helenium (elecampane), together with four known sesquiterpene lactones (2-5). The planar configuration of 1 was elucidated on the basis of spectroscopic data analysis, and the relative configuration of 1 was determined by performing a detailed analysis of NOESY correlations and comparing its physicochemical data with the D- and L-proline adducts of 2 obtained by Michael addition. This is the first report of a new amino acid-sesquiterpene adduct from Inula plants.
从土木香（Inula helenium）的根中分离出一种新的氨基酸 - 倍半萜加合物异土木脯氨酸（1），以及四种已知的倍半萜内酯（2 - 5）。通过光谱数据分析阐明了1的平面构型，并通过对核欧沃豪斯效应（NOESY）相关进行详细分析，并将其物理化学数据与通过迈克尔加成得到的2的D - 和L - 脯氨酸加合物进行比较，确定了1的相对构型。这是首次报道从旋覆花属植物中分离出新型氨基酸 - 倍半萜加合物。
