Johnson R A, Harper N J, Chadwick S, Vohra A
Department of Anaesthesia, Manchester Royal Infirmary.
Anaesthesia. 1990 Jun;45(6):439-42. doi: 10.1111/j.1365-2044.1990.tb14328.x.
A controlled randomised double-blind design was used to study the effect of lignocaine on the pain produced by intravenous injection of propofol. Patients received a 2-ml pretreatment solution with temporary venous occlusion, followed by an induction solution. One hundred and three patients were assigned to one of five groups: saline pretreatment, followed by induction with propofol plus saline 2 ml; lignocaine 20 mg pretreatment, followed by induction with propofol plus saline 2 ml; lignocaine 40 mg pretreatment, followed by induction with propofol plus saline 2 ml; saline pretreatment, followed by induction with propofol plus lignocaine 20 mg; or saline pretreatment, followed by induction with propofol plus lignocaine 40 mg. Pain was reduced significantly in all groups in which lignocaine was used and a dose of 40 mg was more effective than 20 mg. There were no significant differences in the incidence of pain among the groups which received lignocaine as pretreatment and the groups which received lignocaine mixed with propofol. Sixty-eight percent of patients who experienced pain or discomfort recalled it in the postoperative period.
采用对照随机双盲设计研究利多卡因对静脉注射丙泊酚所致疼痛的影响。患者在静脉暂时阻断的情况下接受2毫升预处理溶液，随后接受诱导溶液。103例患者被分为五组之一：生理盐水预处理，随后用丙泊酚加2毫升生理盐水诱导；20毫克利多卡因预处理，随后用丙泊酚加2毫升生理盐水诱导；40毫克利多卡因预处理，随后用丙泊酚加2毫升生理盐水诱导；生理盐水预处理，随后用丙泊酚加20毫克利多卡因诱导；或生理盐水预处理，随后用丙泊酚加40毫克利多卡因诱导。所有使用利多卡因的组疼痛均显著减轻，40毫克剂量比20毫克更有效。接受利多卡因预处理的组与接受利多卡因与丙泊酚混合的组之间疼痛发生率无显著差异。经历疼痛或不适的患者中有68%在术后仍记得。
