National Institute of Health and Clinical Excellence Scholar, Department of Vascular Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
J Surg Res. 2011 Dec;171(2):700-8. doi: 10.1016/j.jss.2011.07.007. Epub 2011 Aug 10.
Cutaneous wound healing is a complex process with many types of mechanical forces regulating the quality and speed of healing. The role of mechanical forces in regulating tissue growth, repair and remodelling was recognised more than a century ago. Such forces influence gene expression, the synthesis of growth factors and inflammatory mediators and cellular processes like proliferation of many load-sensitive cells. However, the exact mechanisms by which these forces interact with cells and ways to use them to stimulate tissues are still active research fronts. This article sets to review the literature on mechanical forces and their role in cutaneous wound healing.
皮肤伤口愈合是一个复杂的过程，有许多类型的机械力调节愈合的质量和速度。机械力在调节组织生长、修复和重塑中的作用早在一个多世纪前就被认识到了。这些力影响基因表达、生长因子和炎症介质的合成以及许多负载敏感细胞的增殖等细胞过程。然而，这些力与细胞相互作用的确切机制以及利用它们来刺激组织的方法仍然是活跃的研究前沿。本文旨在综述机械力及其在皮肤伤口愈合中的作用的文献。
