Ortonne J P, Clévy J P
Service de dermatologie, hôpital Pasteur, Nice.
Rev Prat. 1994 Sep 1;44(13):1733-7.
Cutaneous wound healing involves a well-coordinated cascade of cellular and molecular events in which biological processes such as proliferation, differentiation and cell migration play a key-role. Many different cell types including epithelial and mesenchymal cells are concerned. Cutaneous wound repair can be described as a three stages process: an initial inflammatory stage followed by a proliferative and repair phase ending by a remodeling stage, that overlap in time. A large number of diffusible factors (cytokines, growth factors ...) regulating these different stages have been characterized. Their therapeutic use is presently under investigation.
皮肤伤口愈合涉及一系列细胞和分子事件的协调级联反应，其中增殖、分化和细胞迁移等生物学过程起着关键作用。许多不同类型的细胞，包括上皮细胞和间充质细胞都参与其中。皮肤伤口修复可描述为一个三个阶段的过程：初始炎症阶段，随后是增殖和修复阶段，最后是重塑阶段，这些阶段在时间上相互重叠。大量调节这些不同阶段的可扩散因子（细胞因子、生长因子等）已被鉴定。目前正在研究它们的治疗用途。
