Department of Surgery, University of Colorado-Denver, CO, USA.
Shock. 2011 Nov;36(5):524-6. doi: 10.1097/SHK.0b013e31822dc518.
Thromboelastography (TEG), used in liver transplant and cardiac surgery for nearly 50 years, has recently been applied to the trauma setting. Rodents are used widely for shock research, but are known to have differences in their coagulation system compared with humans. Consequently, the appropriate technique for performing TEG requires modification of the standard clinical protocol. Thromboelastography was performed with blood collected from the femoral artery of rodents, and technical modifications were tested to optimize results. Analysis of citrated whole blood using TEG revealed a more rapid onset of coagulation in rats compared with humans. The reference ranges of TEG parameters for Sprague-Dawley rats are detailed. Citrated native whole blood is the optimal TEG method in the assessment of coagulation in rodents. Investigators using TEG for research purposes should establish their own reference ranges to determine normal values for their target population.
血栓弹力描记术（TEG）在肝移植和心脏手术中应用近 50 年，最近已应用于创伤领域。啮齿动物被广泛用于休克研究，但已知其凝血系统与人类存在差异。因此，需要对标准临床方案进行修改，以实现 TEG 的适当操作。从啮齿动物的股动脉采集血液进行 TEG，测试技术修改以优化结果。使用 TEG 对柠檬酸化全血进行分析表明，与人类相比，大鼠凝血的起始更快。详细介绍了 Sprague-Dawley 大鼠 TEG 参数的参考范围。在评估啮齿动物的凝血时，柠檬酸化的天然全血是 TEG 的最佳方法。研究人员出于研究目的而使用 TEG 时，应建立自己的参考范围，以确定其目标人群的正常值。
