Department of Neurocritical Care, The National Hospital for Neurology and Neurosurgery, University College London Hospitals, Queen Square, London WC1N 3BG, UK.
Philos Trans A Math Phys Eng Sci. 2011 Nov 28;369(1955):4452-69. doi: 10.1098/rsta.2011.0242.
Near-infrared spectroscopy (NIRS) has potential as a non-invasive brain monitor in a wide range of clinical scenarios. In the last decade, there has been a rapid expansion of clinical experience using NIRS to monitor cerebral oxygenation, particularly in cardiac surgery, where there is some evidence that NIRS-guided brain protection protocols might lead to a reduction in peri-operative neurological complications. There are no data to support the wider application of NIRS to monitor cerebral oxygenation during routine anaesthesia and surgery, and its application in brain injury, where it might be expected to have a key monitoring role, is as yet undefined. Technological developments, including the introduction of broadband and time-resolved spectrometers that are capable of reliably measuring changes in oxidized cytochrome c oxidase, offer real potential for a single NIRS-based device to provide multi-site, regional monitoring of cerebral metabolic status as well as oxygenation and haemodynamics.
近红外光谱（NIRS）作为一种在广泛临床情况下的非侵入性脑监测方法具有潜力。在过去的十年中，使用 NIRS 监测脑氧合的临床经验迅速增加，特别是在心脏手术中，有证据表明 NIRS 指导的脑保护方案可能会减少围手术期神经系统并发症。没有数据支持将 NIRS 更广泛地应用于常规麻醉和手术期间的脑氧合监测，而在脑损伤中，人们可能期望它发挥关键的监测作用，但目前尚未确定。技术的发展，包括引入能够可靠测量氧化细胞色素 c 氧化酶变化的宽带和时间分辨光谱仪，为单个基于 NIRS 的设备提供多部位、区域性脑代谢状态以及氧合和血液动力学监测提供了真正的潜力。
