Truong Nghi Cong Dung, Wang Xinlong, Wanniarachchi Hashini, Liu Hanli
Department of Bioengineering, University of Texas at Arlington, Arlington, TX, United States.
Front Neurosci. 2022 Jun 10;16:896502. doi: 10.3389/fnins.2022.896502. eCollection 2022.
Transcranial photobiomodulation (tPBM) has been considered a safe and effective brain stimulation modality being able to enhance cerebral oxygenation and neurocognitive function. To better understand the underlying neurophysiological effects of tPBM in the human brain, we utilized a 111-channel functional near infrared spectroscopy (fNIRS) system to map cerebral hemodynamic responses over the whole head to 8-min tPBM with 1,064-nm laser given on the forehead of 19 healthy participants. Instead of analyzing broad-frequency hemodynamic signals (0-0.2 Hz), we investigated frequency-specific effects of tPBM on three infra-slow oscillation (ISO) components consisting of endogenic, neurogenic, and myogenic vasomotions. Significant changes induced by tPBM in spectral power of oxygenated hemoglobin concentration (Δ[HbO]), functional connectivity (FC), and global network metrics at each of the three ISO frequency bands were identified and mapped topographically for frequency-specific comparisons. Our novel findings revealed that tPBM significantly increased endogenic Δ[HbO] powers over the right frontopolar area near the stimulation site. Also, we demonstrated that tPBM enabled significant enhancements of endogenic and myogenic FC across cortical regions as well as of several global network metrics. These findings were consistent with recent reports and met the expectation that myogenic oscillation is highly associated with endothelial activity, which is stimulated by tPBM-evoked nitric oxide (NO) release.
经颅光生物调节（tPBM）被认为是一种安全有效的脑刺激方式，能够增强脑氧合和神经认知功能。为了更好地理解tPBM在人脑中潜在的神经生理效应，我们利用一个111通道的功能近红外光谱（fNIRS）系统，对19名健康参与者在前额给予1064纳米激光进行8分钟tPBM刺激时，绘制全脑的脑血流动力学反应图谱。我们没有分析宽频血流动力学信号（0-0.2赫兹），而是研究了tPBM对由内源性、神经源性和肌源性血管运动组成的三个亚慢振荡（ISO）成分的频率特异性影响。确定了tPBM在三个ISO频段中每个频段的氧合血红蛋白浓度光谱功率（Δ[HbO]）、功能连接性（FC）和全局网络指标的显著变化，并进行了地形图绘制以进行频率特异性比较。我们的新发现表明，tPBM显著增加了刺激部位附近右侧额极区的内源性Δ[HbO]功率。此外，我们证明tPBM能够显著增强皮质区域内源性和肌源性FC以及几个全局网络指标。这些发现与最近的报道一致，并符合肌源性振荡与内皮活性高度相关的预期，内皮活性受到tPBM诱发的一氧化氮（NO）释放的刺激。
