Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Cardiol Res Pract. 2011;2011:845170. doi: 10.4061/2011/845170. Epub 2011 Oct 6.
At present, cardiac diseases are a major cause of morbidity and mortality in the world. Recently, a cell-based regenerative medicine has appeared as one of the most potential and promising therapies for improving cardiac diseases. As a new generational cell-based regenerative therapy, tissue engineering is focused. Our laboratory has originally developed cell sheet-based scaffold-free tissue engineering. Three-dimensional myocardial tissue fabricated by stacking cardiomyocyte sheets, which are tightly interconnected to each other through gap junctions, beats simultaneously and macroscopically and shows the characteristic structures of native heart tissue. Cell sheet-based therapy cures the damaged heart function of animal models and is clinically applied. Cell sheet-based tissue engineering has a promising and enormous potential in myocardial tissue regenerative medicine and will cure many patients suffering from severe cardiac disease. This paper summarizes cell sheet-based tissue engineering and its satisfactory therapeutic effects on cardiac disease.
目前，心脏病是世界范围内发病率和死亡率的主要原因。最近，一种基于细胞的再生医学作为改善心脏病的最有潜力和最有前途的疗法之一出现了。作为新一代基于细胞的再生疗法，组织工程备受关注。我们的实验室最初开发了基于细胞片的无支架组织工程。通过堆叠心肌细胞片来制造三维心肌组织，这些细胞片通过缝隙连接紧密地相互连接，能够同步、宏观地跳动，并显示出原生心脏组织的特征结构。基于细胞片的治疗方法可以治愈动物模型的受损心脏功能，并已在临床上应用。基于细胞片的组织工程在心肌组织再生医学方面具有广阔的应用前景，将治愈许多患有严重心脏病的患者。本文总结了基于细胞片的组织工程及其在心脏病治疗方面的令人满意的疗效。
