Epidemiology Data Center, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Clin Exp Hypertens. 2012;34(1):63-70. doi: 10.3109/10641963.2011.618200. Epub 2011 Oct 18.
Circulating aldosterone is increased in obesity and is associated with arterial stiffening in hypertensives and older adults. The aim of this article was to determine whether serum aldosterone is associated with pulse wave velocity (PWV), a measure of arterial stiffness, in normotensive overweight and obese adults aged 20-45 years (n = 344). Heart-femoral, femoral-ankle, and brachial-ankle PWV were measured. The sample was 77% female with mean body mass index 32.9 kg/m(2) (SD 3.9), median serum aldosterone 106.5 pg/mL (interquartile range 79.9, 155.5), and mean 24-hour urinary sodium excretion 185.9 mEq/day (SD 69.6). Higher serum aldosterone was not significantly correlated with any PWV measure in bivariate analysis. However, in multiple linear regression, adjusting for age, sex, race, height, heart rate, mean arterial pressure, and waist circumference, higher log aldosterone was associated with greater log heart-femoral PWV (β(se) = 0.042(0.021), P = .049). After adjusting for C-reactive protein, this association was no longer significant (β(se) = 0.035(0.021), P = .10). Circulating aldosterone may play an important role in vascular inflammation and aortic stiffening in normotensive overweight and obese adults.
循环中的醛固酮在肥胖症中增加，并且与高血压和老年人的动脉僵硬有关。本文的目的是确定在 20-45 岁的血压正常超重和肥胖成年人中，血清醛固酮是否与脉搏波速度（PWV），即动脉僵硬的一种衡量标准有关（n=344）。测量了心-股、股-踝和肱-踝 PWV。该样本中 77%为女性，平均体重指数为 32.9kg/m²（标准差为 3.9），中位数血清醛固酮为 106.5pg/ml（四分位间距为 79.9，155.5），平均 24 小时尿钠排泄量为 185.9mEq/天（标准差为 69.6）。在双变量分析中，较高的血清醛固酮与任何 PWV 测量均无显著相关性。然而，在多元线性回归中，调整年龄、性别、种族、身高、心率、平均动脉压和腰围后，较高的对数醛固酮与较大的对数心-股 PWV 相关（β（se）=0.042（0.021），P=0.049）。调整 C 反应蛋白后，这种相关性不再显著（β（se）=0.035（0.021），P=0.10）。循环中的醛固酮可能在血压正常超重和肥胖成年人的血管炎症和主动脉僵硬中起重要作用。
