Sanders-Brown Center on Aging, University of Kentucky, Lexington, USA.
Am J Alzheimers Dis Other Demen. 2011 Sep;26(6):469-76. doi: 10.1177/1533317511423020. Epub 2011 Oct 18.
Historically, minority groups have been underrepresented in research and clinical trials. The lack of participation by minorities has been attributed to a variety of factors including a mistrust of the predominately white research establishments and a lack of education about the purpose of research. The current study was designed to determine African American interest in Alzheimer's disease (AD) research and to recruit African Americans as normal controls in current AD studies with the goal of eventually gaining consent for brain donation upon death. Participants were 46 African Americans aged 65 or older, who were interviewed about the knowledge of medical procedures and experience with research. After initial recruitment interviews, 31.7% of participants agreed to yearly testing with eventual brain donation. Study findings suggest a moderate relationship between participants' knowledge of medical procedures used to prolong life and willingness to donate one's brain.
从历史上看，少数群体在研究和临床试验中的代表性不足。少数群体参与度低的原因有很多，包括对以白种人为主的研究机构的不信任，以及对研究目的缺乏了解。本研究旨在确定非裔美国人对阿尔茨海默病（AD）研究的兴趣，并招募非裔美国人作为当前 AD 研究中的正常对照组，最终目标是在死亡后获得大脑捐赠的同意。参与者为 46 名年龄在 65 岁或以上的非裔美国人，他们接受了关于医疗程序知识和研究经验的采访。在最初的招募访谈后，31.7%的参与者同意每年进行测试，最终捐赠大脑。研究结果表明，参与者对用于延长生命的医疗程序的了解程度与捐赠大脑的意愿之间存在中等程度的关系。
