Fejzo Marlena S, Ching Chunyu, Schoenberg Frederic P, Macgibbon Kimber, Romero Roberto, Goodwin T Murphy, Mullin Patrick M
Department of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J Matern Fetal Neonatal Med. 2012 Aug;25(8):1241-5. doi: 10.3109/14767058.2011.632039. Epub 2011 Nov 24.
To determine whether change in paternity changes recurrence risk of hyperemesis gravidarum (HG).
Survey data on recurrence of HG was compared between cases who had a paternity change between pregnancies and cases who did not.
The percentage of HG pregnancies in women with the same partner for all pregnancies was not significantly different from the percentage of HG pregnancies in women who changed partners for at least one pregnancy (78% vs 71%, p > 0.05). Participants who did and did not change partners between their first and second pregnancies, were asked to rate their first and second pregnancy in regards to symptoms of HG. Neither the ratings nor the change in rating between pregnancies was significantly different between the two groups.
Women reported HG in over 70% of their pregnancies regardless of a paternity change. Paternal genes expressed through the fetus do not have a significant effect on incidence or recurrence of HG. This study supports a strong maternal genetic factor involved in HG. However, because the recurrence risk is not 100%, other factors play a role. Identification of the predisposing gene(s) and other factors will determine the cause of this poorly understood complication of pregnancy.
确定父亲身份的改变是否会改变妊娠剧吐（HG）的复发风险。
比较了妊娠期间父亲身份发生改变的病例与未发生改变的病例中HG复发的调查数据。
所有妊娠均与同一伴侣的女性中HG妊娠的百分比与至少有一次妊娠更换伴侣的女性中HG妊娠的百分比无显著差异（78%对71%，p>0.05）。在第一次和第二次妊娠之间更换或未更换伴侣的参与者被要求对其第一次和第二次妊娠的HG症状进行评分。两组之间的评分以及妊娠期间评分的变化均无显著差异。
无论父亲身份是否改变，女性报告超过70%的妊娠有HG。通过胎儿表达的父系基因对HG的发生率或复发没有显著影响。本研究支持HG存在强大的母体遗传因素。然而，由于复发风险并非100%，其他因素也起作用。确定易感基因和其他因素将有助于明确这种妊娠并发症的病因，目前该并发症仍了解不足。
