首次证明患有妊娠剧吐的一部分女性在前庭眼反射通路存在异常。
The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway.
作者信息
Goodwin Thomas Murphy, Nwankwo Odinaka A, O'Leary Linda Davis, O'Leary Dennis, Romero Roberto, Korst Lisa M
机构信息
Department of Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
出版信息
Am J Obstet Gynecol. 2008 Oct;199(4):417.e1-9. doi: 10.1016/j.ajog.2008.07.003.
OBJECTIVE
The vestibular system is a major pathway to nausea and vomiting, and the vestibuloocular reflex (VOR) is a central component; its function can be studied using the vestibular autorotation test (VAT). We hypothesize that women with hyperemesis gravidarum (HG) may have VOR abnormalities.
STUDY DESIGN
Women with HG were compared with women without HG using the VAT. Horizontal and vertical VOR gains and phases were evaluated at 3 frequency ranges: low (2.0 to 3.5 Hz), medium (greater than 3.5 to 5.0 Hz), and high (greater than 5.0 to 6.0 Hz) during pregnancy and postpartum.
RESULTS
Twenty women with HG and 48 unaffected women were evaluated in early pregnancy. Women with HG had higher horizontal gains at all 3 frequency ranges. Horizontal phase differences were also observed at medium frequencies. No VAT differences were noted postpartum.
CONCLUSION
Women experiencing HG had a higher mean VOR horizontal gain and lower horizontal phase when compared with unaffected women.
目的
前庭系统是引发恶心和呕吐的主要途径，前庭眼反射（VOR）是其核心组成部分；可通过前庭自动旋转试验（VAT）来研究其功能。我们假设妊娠剧吐（HG）女性可能存在VOR异常。
研究设计
使用VAT对HG女性与非HG女性进行比较。在妊娠期间和产后，于3个频率范围评估水平和垂直VOR增益及相位：低频率（2.0至3.5赫兹）、中频率（大于3.5至5.0赫兹）和高频率（大于5.0至6.0赫兹）。
结果
在妊娠早期对20名HG女性和48名未受影响的女性进行了评估。HG女性在所有3个频率范围均有较高的水平增益。在中频率时也观察到水平相位差异。产后未发现VAT差异。
结论
与未受影响的女性相比，经历HG的女性平均VOR水平增益更高，水平相位更低。
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