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妊娠早期和中期阴道出血与早产之间的关系。

The relationship between vaginal bleeding in the first and second trimester of pregnancy and preterm labor.

作者信息

Sharami Seyedeh Hajar, Faraji Darkhaneh Roya, Zahiri Ziba, Milani Forozan, Asgharnia Maryam, Shakiba Maryam, Didar Zirak

机构信息

Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.

Guilan University of Medical Sciences, Rasht, Iran.

出版信息

Iran J Reprod Med. 2013 May;11(5):385-90.

Abstract

BACKGROUND

Vaginal bleeding is a common complication during pregnancy, which is observed in about 1/4 of pregnancies and in half of cases can lead to abortion. If vaginal bleeding happens during pregnancy some adverse pregnancy outcomes, including perinatal mortality and morbidity, low birth weight and preterm delivery will be increased.

OBJECTIVE

The aim of this study was to determine the relationship between vaginal bleeding and its characteristics in the first and second trimester of pregnancy and preterm labor.

MATERIALS AND METHODS

This is a case-control study conducted on 440 pregnant women referred to Al-Zahra Hospital in Rasht, Iran. Data were collected by a form. The form included demographic characteristics and confounding factors, the occurrence of bleeding during pregnancy and its features. Data were analyzed by T test, chi square and logistic regression in SPSS 16.

RESULTS

Findings showed that vaginal bleeding was associated with 3 times increased risk of preterm delivery (OR: 3, 1.84-4.89). Also, findings showed that bleeding characteristics including bleeding time, frequency, severity and intensity was significantly associated with preterm labor.

CONCLUSION

According to significant association between vaginal bleeding and preterm delivery, it seems that performing some interventions to prevent preterm labor could be appropriate.

摘要

背景

孕期阴道出血是一种常见并发症,约四分之一的妊娠会出现这种情况,其中半数病例可能导致流产。如果孕期发生阴道出血,一些不良妊娠结局,包括围产期死亡率和发病率、低出生体重和早产将会增加。

目的

本研究旨在确定妊娠早期和中期阴道出血及其特征与早产之间的关系。

材料与方法

这是一项对转诊至伊朗拉什特的阿尔扎赫拉医院的440名孕妇进行的病例对照研究。通过一份表格收集数据。该表格包括人口统计学特征和混杂因素、孕期出血的发生情况及其特征。数据在SPSS 16中通过T检验、卡方检验和逻辑回归进行分析。

结果

研究结果显示,阴道出血与早产风险增加3倍相关(比值比:3,1.84 - 4.89)。此外,研究结果表明,出血特征,包括出血时间、频率、严重程度和强度与早产显著相关。

结论

鉴于阴道出血与早产之间存在显著关联,似乎采取一些预防早产的干预措施可能是合适的。

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本文引用的文献

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Risk of preterm delivery in relation to vaginal bleeding in early pregnancy.孕早期阴道出血与早产风险的关系。
Eur J Obstet Gynecol Reprod Biol. 2007 Dec;135(2):158-63. doi: 10.1016/j.ejogrb.2006.12.003. Epub 2007 Jan 4.
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Vaginal bleeding during pregnancy and preterm birth.孕期阴道出血与早产。
Am J Epidemiol. 2004 Jul 15;160(2):118-25. doi: 10.1093/aje/kwh180.
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The role of thrombin in preterm parturition.凝血酶在早产中的作用。
Am J Obstet Gynecol. 2001 Nov;185(5):1059-63. doi: 10.1067/mob.2001.117638.
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Preterm delivery: a public health perspective.早产:公共卫生视角
Paediatr Perinat Epidemiol. 2001 Jul;15 Suppl 2:7-16. doi: 10.1046/j.1365-3016.2001.00004.x.

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