Department of Clinical Sciences - Malmö, Lund University, SE-205 02 Malmö, Sweden.
Br J Nutr. 2012 Apr;107(7):1062-9. doi: 10.1017/S0007114511003783. Epub 2011 Oct 20.
Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.
小而密的 LDL 颗粒血浆浓度升高表示存在致动脉粥样硬化脂蛋白表型 (ALP)，与循环 TAG 升高和 HDL-胆固醇降低相关。亚组分浓度的主成分分析先前已在基于人群的瑞典马尔默饮食与癌症 (MDC) 队列中使用，以确定三个独立的成分，其中一个模式代表 ALP。本研究的目的是检查宏量营养素摄入与代表 ALP 的主成分之间的关联。我们在 MDC 队列的基线检查了 4301 名健康受试者（46-68 岁，60%为女性）。使用改良饮食史法收集饮食数据。使用高分辨率离子淌度法测量血浆脂蛋白亚组分。与 ALP 对应的主成分与双糖的摄入较高显著相关，而与蛋白质和酒精的摄入呈负相关（所有 P < 0·001）。本研究结果表明，通过低双糖摄入以及适量的蛋白质和酒精摄入，可能改善 ALP。
