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利用新型指示菌株肺炎克雷伯菌 ATCC 700603 对铜绿假单胞菌进行敏感且特异的改良 Hodge 试验，以检测 KPC 和金属β-内酰胺酶。

Sensitive and specific modified Hodge test for KPC and metallo-beta- lactamase detection in Pseudomonas aeruginosa by use of a novel indicator strain, Klebsiella pneumoniae ATCC 700603.

机构信息

Servicio Antimicrobianos, INEI-ANLIS Dr. Carlos G. Malbrán, Velez Sarsfield 563 Ave. (C1282AFF), Buenos Aires, Argentina.

出版信息

J Clin Microbiol. 2011 Dec;49(12):4301-3. doi: 10.1128/JCM.05602-11. Epub 2011 Oct 19.

DOI:10.1128/JCM.05602-11
PMID:22012019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3232994/
Abstract

We evaluated the ability of the modified Hodge test to discriminate between KPC- and metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa isolates and carbapenemase nonproducers. With Escherichia coli ATCC 25922 as the indicator strain, the MHT resulted in low sensitivity, specificity, and repeatability. Replacing the indicator strain with Klebsiella pneumoniae ATCC 700603 led to an improved performance (100%, 97%, 0%, and 100% sensitivity, specificity, indeterminate results and repeatability, respectively).

摘要

我们评估了改良 Hodge 试验（MHT）区分产 KPC 和产金属β-内酰胺酶（MBL）铜绿假单胞菌分离株与碳青霉烯酶非产酶株的能力。以大肠埃希菌 ATCC 25922 作为指示菌株时，MHT 的灵敏度、特异性和可重复性均较低。用肺炎克雷伯菌 ATCC 700603 替代指示菌株可改善其性能（分别为 100%、97%、0%和 100%的灵敏度、特异性、不确定结果和可重复性）。

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本文引用的文献

1
A simple test for the detection of KPC and metallo-β-lactamase carbapenemase-producing Pseudomonas aeruginosa isolates with the use of meropenem disks supplemented with aminophenylboronic acid, dipicolinic acid and cloxacillin.使用美罗培南纸片补充氨苯硼酸、吡啶二羧酸和氯唑西林检测产 KPC 和金属β-内酰胺酶碳青霉烯酶铜绿假单胞菌分离株的简单试验。
Clin Microbiol Infect. 2011 Sep;17(9):1438-41. doi: 10.1111/j.1469-0691.2011.03585.x. Epub 2011 Jun 20.
2
Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues.革兰氏阴性细菌病原体中获得性碳青霉烯酶：检测和监测问题。
Clin Microbiol Infect. 2010 Feb;16(2):112-22. doi: 10.1111/j.1469-0691.2009.03116.x.
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Controlling the spread of carbapenemase-producing Gram-negatives: therapeutic approach and infection control.控制产碳青霉烯酶革兰氏阴性菌的传播：治疗方法和感染控制。
Clin Microbiol Infect. 2010 Feb;16(2):102-11. doi: 10.1111/j.1469-0691.2009.03115.x.
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Modified Hodge and EDTA-disk synergy tests to screen metallo-beta-lactamase-producing strains of Pseudomonas and Acinetobacter species.改良 Hodge 试验和 EDTA 纸片协同试验用于筛选产金属β-内酰胺酶的铜绿假单胞菌和不动杆菌属菌株。
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