Tufts University School of Medicine, Department of Neuroscience, Boston, MA 02111, USA.
Trends Neurosci. 2013 Feb;36(2):83-90. doi: 10.1016/j.tins.2012.12.009. Epub 2013 Jan 18.
A considerable body of evidence links diminished brain-derived neurotrophic factor (BDNF) signaling to energy balance dysregulation and severe obesity in humans and rodents. Because BDNF exhibits broad neurotrophic properties, the underpinnings of these effects and its true role in the central regulation of food intake remain topics of debate in the field. Here, I discuss recent evidence supporting a critical role for this neurotrophin in physiological mechanisms regulating nutrient intake and body weight in the mature brain. They include reports of functional interactions of BDNF with central anorexigenic and orexigenic signaling pathways and evidence of recognized appetite hormones exerting neurotrophic effects similar to those of BDNF.
大量证据表明，脑源性神经营养因子（BDNF）信号减弱与人类和啮齿动物的能量平衡失调和严重肥胖有关。由于 BDNF 具有广泛的神经营养特性，这些影响的基础及其在食物摄入的中枢调节中的真正作用仍然是该领域争论的话题。在这里，我讨论了最近的证据，这些证据支持这种神经营养因子在调节成熟大脑中营养摄入和体重的生理机制中的关键作用。其中包括 BDNF 与中枢食欲抑制和食欲刺激信号通路的功能相互作用的报告，以及公认的食欲激素发挥类似于 BDNF 的神经营养作用的证据。
