Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada.
Chem Soc Rev. 2011 Dec;40(12):5647-56. doi: 10.1039/c1cs15253j. Epub 2011 Oct 19.
The powerful self-assembly features of DNA make it a unique template to finely organize and control matter on the nanometre scale. While DNA alone offers a high degree of fidelity in its self-assembly, a new area of research termed 'supramolecular DNA assembly' has recently emerged. This field combines DNA building blocks with synthetic organic, inorganic and polymeric structures. It thus brings together the toolbox of supramolecular chemistry with the predictable and programmable nature of DNA. The result of this molecular partnership is a variety of hybrid architectures, that expand DNA assembly beyond the boundaries of Watson-Crick base pairing into new structural and functional properties. In this tutorial review we outline this emerging field of study, and describe recent research aiming to synergistically combine the properties inherent to DNA with those of a number of supramolecular scaffolds. This ultimately creates structures with numerous potential applications in materials science, catalysis and medicine.
DNA 强大的自组装特性使其成为精细组织和控制纳米尺度物质的独特模板。虽然 DNA 本身在自组装中具有高度的保真度，但最近出现了一个新的研究领域，称为“超分子 DNA 组装”。该领域将 DNA 构建块与合成有机、无机和聚合物结构结合在一起。因此，它将超分子化学的工具包与 DNA 的可预测和可编程性质结合在一起。这种分子伙伴关系的结果是各种混合结构，将 DNA 组装扩展到 Watson-Crick 碱基配对的边界之外，产生新的结构和功能特性。在本教程综述中，我们概述了这一新兴的研究领域，并描述了最近旨在协同结合 DNA 固有特性与多种超分子支架特性的研究。这最终创造出具有许多在材料科学、催化和医学中具有潜在应用的结构。
