Department of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden.
J Med Virol. 2011 Dec;83(12):2135-42. doi: 10.1002/jmv.22243.
Data regarding prevalence of noroviruses (NoVs) among asymptomatic persons are scarce. The current study carried out on samples from Cameroon describes the asymptomatic shedding of NoVs and other enteric viruses in healthy children and in adults infected with HIV but lacking symptoms of gastroenteritis. Enteric viruses were common with a prevalence of 53.7% in the children, and 35.5% in the adult participants. Multiple enteric viruses (2-5 agents) were detected in fecal samples from 65% of the children, and co-infection with NoV was demonstrated in almost all cases of multiple infections. NoV viral loads in the healthy children were within disease causing range and significantly higher than those observed in the adults (P < 0.01). Sequencing and genotyping of NoV strains by phylogeny showed a marked diversity within two distinct genogroups, GI and GII, and strains clustered with genotypes GI.3, GII.17, GII.8, and GII.4. Genetic similarities to recent outbreak strains from other continents suggest a rapid circulation of NoVs that includes healthy children, who may constitute a reservoir for pathogenic NoVs.
关于无症状者中诺如病毒（NoV）流行率的数据很少。本研究在喀麦隆的样本中进行，描述了无症状的 NoV 和其他肠道病毒在健康儿童和感染 HIV 但无肠胃炎症状的成人中的脱落情况。肠道病毒很常见，儿童的流行率为 53.7%，成人参与者为 35.5%。在 65%的儿童粪便样本中检测到多种肠道病毒（2-5 种病原体），几乎所有多重感染的病例都证实存在 NoV 共同感染。健康儿童的 NoV 病毒载量在致病范围内，明显高于成人（P<0.01）。通过系统发育对 NoV 株进行测序和基因分型显示，在两个不同的基因群 GI 和 GII 内存在明显的多样性，并且株与基因型 GI.3、GII.17、GII.8 和 GII.4 聚类。与来自其他大洲的最近暴发株的遗传相似性表明 NoV 的快速循环，包括健康儿童，他们可能是致病性 NoV 的储主。
