State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Physiology (Bethesda). 2011 Oct;26(5):314-25. doi: 10.1152/physiol.00020.2011.
It is well documented that female fertility is decreased with advanced maternal age due to chromosome abnormality in oocytes. Increased chromosome missegregation is mainly caused by centromeric cohesion reduction. Other factors such as weakened homologous recombination, improper spindle organization, spindle assembly checkpoint (SAC) malfunction, chromatin epigenetic changes, and extra-oocyte factors may also cause chromosome errors.
大量文献表明，由于卵子中的染色体异常，女性生育能力会随着年龄的增长而下降。着丝粒凝聚减少是导致染色体错误分离的主要原因。其他因素，如同源重组减弱、纺锤体组织不当、纺锤体组装检查点（SAC）功能障碍、染色质表观遗传改变和卵外因素，也可能导致染色体错误。
