Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, Arizona 86011, USA.
Chem Res Toxicol. 2011 Nov 21;24(11):1830-2. doi: 10.1021/tx200410x. Epub 2011 Oct 26.
Uranium is an important emerging toxicant whose use has outpaced the rate at which we are learning about its health effects. One unexplored pathway for uranium toxicity involves the photoactivation of uranyl ion by UV light to produce U(5+) and oxygen radicals. The purpose of this study was to provide proof of principle data by testing the hypothesis that coexposures of DNA to uranyl acetate and UVB irradiation should produce more DNA strand breaks than individual exposures. Results supported the hypothesis and suggest that investigations of uranium toxicity be expanded to include skin as a potential target organ for carcinogenesis, especially in populations with high uranium and high UV radiation exposures.
铀是一种重要的新兴毒性物质，其使用速度超过了我们了解其健康影响的速度。铀毒性的一个未探索途径涉及铀酰离子被紫外光光解，生成 U(5+)和氧自由基。本研究的目的是通过测试以下假设来提供原理性证据，即 DNA 同时暴露于乙酸铀酰和 UVB 辐射下应比单独暴露产生更多的 DNA 链断裂：同时暴露于乙酸铀酰和 UVB 辐射下应比单独暴露产生更多的 DNA 链断裂。结果支持了这一假设，并表明应将铀毒性的研究扩展到包括皮肤作为潜在的致癌作用靶器官，特别是在铀和紫外线辐射暴露水平高的人群中。
