Okuni Julius Boniface, Hansen Sören, Eltom Kamal H, Eltayeb ElSagad, Amanzada Ahmad, Omega Joseph Amesa, Czerny Claus Peter, Abd El Wahed Ahmed, Ojok Lonzy
College of Veterinary Medicine, Animal Resources and Biosecurity (COVAB), Makerere University, P. O. Box 7062 Kampala, Uganda.
Division of Microbiology and Animal Hygiene, University of Goettingen, D-37077 Goettingen, Germany.
Microorganisms. 2020 Jul 5;8(7):1007. doi: 10.3390/microorganisms8071007.
The subspecies (MAP) is the causative agent of paratuberculosis, which is an economically important disease of ruminants. The zoonotic role of MAP in Crohn's disease and, to a lesser extent, in ulcerative colitis, the two major forms of idiopathic inflammatory bowel disease (IIBD), has been debated for decades and evidence continues to mount in support of that hypothesis. The aim of this paper is to present a review of the current information on paratuberculosis in animals and the two major forms of IIBD in Africa. The occurrence, epidemiology, economic significance and "control of MAP and its involvement IIBD in Africa" are discussed. Although the occurrence of MAP is worldwide and has been documented in several African countries, the epidemiology and socioeconomic impacts remain undetermined and limited research information is available from the continent. At present, there are still significant knowledge gaps in all these areas as far as Africa is concerned. Due to the limited research on paratuberculosis in Africa, in spite of growing global concerns, it may rightfully be considered a neglected tropical disease with a potentially zoonotic role.
副结核分枝杆菌亚种（MAP）是副结核病的病原体，副结核病是反刍动物一种具有重要经济影响的疾病。几十年来，MAP在克罗恩病以及在较小程度上在溃疡性结肠炎（特发性炎症性肠病（IIBD）的两种主要形式）中的人畜共患病作用一直存在争议，且支持该假说的证据不断增加。本文旨在综述非洲动物副结核病以及IIBD两种主要形式的现有信息。讨论了MAP在非洲的发生情况、流行病学、经济意义及防控以及其与IIBD的关联。尽管MAP在全球范围内存在且在几个非洲国家已有记录，但流行病学及社会经济影响仍未明确，且该大陆的相关研究信息有限。就非洲而言，目前在所有这些领域仍存在重大知识空白。由于非洲对副结核病的研究有限，尽管全球关注度不断提高，但它仍可被合理地视为一种具有潜在人畜共患病作用的被忽视热带病。
