Department of Neurology, Inselspital, University of Bern, Bern, Switzerland.
Lancet Neurol. 2011 Nov;10(11):1002-14. doi: 10.1016/S1474-4422(11)70229-0.
The clinical presentation of basilar artery occlusion (BAO) ranges from mild transient symptoms to devastating strokes with high fatality and morbidity. Often, non-specific prodromal symptoms such as vertigo or headaches are indicative of BAO, and are followed by the hallmarks of BAO, including decreased consciousness, quadriparesis, pupillary and oculomotor abnormalities, dysarthria, and dysphagia. When clinical findings suggest an acute brainstem disorder, BAO has to be confirmed or ruled out as a matter of urgency. If BAO is recognised early and confirmed with multimodal CT or MRI, intravenous thrombolysis or endovascular treatment can be undertaken. The goal of thrombolysis is to restore blood flow in the occluded artery and salvage brain tissue; however, the best treatment approach to improve clinical outcome still needs to be ascertained.
基底动脉闭塞(BAO)的临床表现范围从轻度短暂症状到致命性和高发病率的中风。通常,非特异性前驱症状,如眩晕或头痛,提示存在 BAO,随后出现 BAO 的特征症状,包括意识降低、四肢瘫痪、瞳孔和眼动异常、构音障碍和吞咽困难。当临床发现提示急性脑干障碍时,必须紧急确认或排除 BAO。如果 BAO 早期得到识别,并通过多模态 CT 或 MRI 得到确认,则可以进行静脉溶栓或血管内治疗。溶栓的目的是恢复闭塞动脉的血流并挽救脑组织;然而,仍需要确定改善临床结果的最佳治疗方法。