Department of Urology, Rize University School of Medicine, Rize, Turkey.
Urology. 2012 Jan;79(1):72-5. doi: 10.1016/j.urology.2011.08.050. Epub 2011 Oct 19.
To investigate the relevance of metabolic syndrome in the etiopathogenesis of overactive bladder in female patients. It has been shown that obesity has been associated with overactive bladder (OAB), and the metabolic syndrome and insulin resistance have been related to the annual growth rates of prostate and lower urinary tract symptoms.
Female patients applying to our policlinics with OAB symptoms or other urologic complaints were enrolled in the study. The International Diabetes Federation criteria were used for the definition of the metabolic syndrome. The chi-square, Student t, and Mann-Whitney U tests and logistic regression analyses were used to compare differences in the variables.
The metabolic syndrome was diagnosed in 201 (64%) of 313 patients with OAB and 73 (35%) of 208 patients without OAB. The difference was statistically significant (P=.002). A larger waist circumference, greater body mass index, low high-density lipoprotein level, and incidence of hypertension were significantly greater statistically in the OAB group than in the controls.
The metabolic syndrome correlates highly with OAB in female patients. The metabolic syndrome can be an etiologic pathway for the onset of symptoms.
探讨代谢综合征与女性患者膀胱过度活动症发病机制的相关性。肥胖与膀胱过度活动症（OAB）有关，代谢综合征和胰岛素抵抗与前列腺和下尿路症状的年增长率有关。
本研究纳入了因 OAB 症状或其他泌尿科疾病到我院门诊部就诊的女性患者。采用国际糖尿病联合会标准定义代谢综合征。采用卡方检验、学生 t 检验、Mann-Whitney U 检验和逻辑回归分析比较变量之间的差异。
在 313 例 OAB 患者和 208 例非 OAB 患者中，诊断出代谢综合征分别为 201 例（64%）和 73 例（35%）。差异具有统计学意义（P=.002）。OAB 组的腰围更大、体重指数更高、高密度脂蛋白水平更低、高血压发病率显著高于对照组。
代谢综合征与女性患者的 OAB 高度相关。代谢综合征可能是症状发生的一个病因途径。
