Department of Dermatology, Mount Sinai School of Medicine, New York, NY, USA.
Clin Dermatol. 2011 Nov-Dec;29(6):652-61. doi: 10.1016/j.clindermatol.2011.08.026.
Isotretinoin has revolutionized the field of dermatology, offering a cure for severe acne vulgaris and a therapeutic option for a variety of other chronic diseases and cancers. This drug has done more for many diseases in medicine than many drug classes have done for a single disorder, and yet, its use and availability have been threatened in the United States. Federal restrictions in the form of the IPLEDGE teratogenicity prevention plan have made the use of this drug more complex. Millions of dollars in litigation and claims of injury have fueled hysteria among laymen about the use of this drug. Overwhelmed with worries of its potential adverse effects, the public forgets that withholding isotretinoin therapy is not without its own risks. Isoteretinoin therapy can prevent lifelong and permanent physical and psychological scarring that comes as a matter of course with severe acne. Over 20 million people worldwide have taken the drug, with several studies demonstrating its safety and few long term adverse effects. This wonder drug's continued availability depends upon its responsible and informed use. This paper will review and put in perspective the issues important to consider in the proper use of isotretinoin.
异维 A 酸彻底改变了皮肤科领域，为严重痤疮提供了治愈方法，并为多种其他慢性疾病和癌症提供了治疗选择。这种药物在医学上对许多疾病的贡献超过了许多药物类别对单一疾病的贡献，但在美国，它的使用和供应受到了威胁。联邦政府以 IPLEDGE 致畸预防计划的形式实施的限制，使得这种药物的使用变得更加复杂。数以百万计的诉讼和伤害索赔在非专业人士中引发了对这种药物使用的恐慌。公众对其潜在副作用的担忧让他们忘记了，不进行异维 A 酸治疗也并非没有风险。异维 A 酸治疗可以预防严重痤疮带来的终身和永久性身体和心理创伤。全世界有超过 2000 万人服用过这种药物，多项研究证明了其安全性，且长期不良反应很少。这种神奇药物的持续供应取决于其负责任和知情的使用。本文将回顾和分析在异维 A 酸合理使用中需要考虑的重要问题。
