Prestige and Female Beauty R&D, P&G Innovation Godo Kaisha, 1-17 Koyo-cho Naka, Higashinada-ku, Kobe 658-0032, Japan.
J Dermatol Sci. 2011 Dec;64(3):229-36. doi: 10.1016/j.jdermsci.2011.09.009. Epub 2011 Sep 29.
Facial appearance is regarded as a typical index of ageing. However, people of the same age do not necessarily show the same degree of the facial appearance. The ageing of facial skin proceeds relatively slowly and therefore requires long-term follow-up to elucidate the mechanism of ageing changes.
The purpose of this study was to identify facial skin parameters contributing the subjective impression of the overall ageing and characterize the degree of skin ageing by a 11 year longitudinal skin monitoring.
One-hundred-eight healthy Japanese females excluded outside workers aged 5-64 at 1999, and lived in Akita, Japan till 2010 were enrolled. Facial images were collected to quantify various skin optical parameters. Skin colour, hydration and barrier function were measured with Chromameter, Corneometer and TEWAmeter, respectively. The visual evaluation of the overall facial skin ageing impression was also carried out. The skin parameters contributing visible impression of skin ageing were identified by variable importance in projection analysis, and the degree of facial skin ageing over 11 years was statistically classified by a cluster analysis.
Facial skin parameters that comprehensively influenced visible skin ageing, including hyperpigmented spots, wrinkles and texture were studied. The Skin Ageing Score calculated from these three skin factors was used to classify the subjects into a mild, age-appropriate, and severe skin ageing group. The mild skin ageing group maintained significant better both skin optical and physical conditions.
Variability and classification of the degree of facial skin ageing appearance were studied from this longitudinal research.
面部外观被认为是衰老的典型指标。然而，同年龄段的人并不一定表现出相同程度的面部外观。面部皮肤的衰老过程相对较慢，因此需要长期随访才能阐明衰老变化的机制。
本研究旨在确定对面部皮肤外观整体老化有贡献的参数，并通过 11 年的纵向皮肤监测来描述皮肤老化的程度。
1999 年，108 名居住在日本秋田的健康日本女性（排除户外工作者），年龄在 5-64 岁之间，参加了这项研究。采集面部图像以量化各种皮肤光学参数。使用色度计、皮脂计和 TEWAmeter 分别测量皮肤颜色、水分和屏障功能。还进行了整体面部皮肤老化印象的视觉评估。通过投影变量重要性分析确定对面部皮肤老化外观有明显影响的皮肤参数，并通过聚类分析对 11 年内的面部皮肤老化程度进行统计学分类。
研究了综合影响可见皮肤老化的面部皮肤参数，包括色素沉着斑、皱纹和纹理。从这三个皮肤因素计算得出的皮肤老化评分用于将受试者分为轻度、年龄适宜和重度皮肤老化组。轻度皮肤老化组在皮肤光学和物理条件方面均保持显著优势。
从这项纵向研究中研究了面部皮肤老化外观的可变性和分类。
