Boullart A C I, de Graaf J, Stalenhoef A F
Department of Internal Medicine, Division of Vascular Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Biochim Biophys Acta. 2012 May;1821(5):867-75. doi: 10.1016/j.bbalip.2011.10.002. Epub 2011 Oct 8.
Dyslipidemia, especially elevated serum levels of cholesterol, is causally related to cardiovascular disease. The specific role of triglycerides has long been controversial. In this article we discuss the role of serum triglycerides in relation to the risk of cardiovascular disease. First, the (patho)physiology of triglycerides is described, including the definition and a short summary of the primary and secondary causes of hypertriglyceridemia. Furthermore, we will give an overview of the published epidemiological studies concerning hypertriglyceridemia and cardiovascular disease to support the view that triglyceride-rich lipoproteins are an independently associated risk factor. Finally, treatment strategies and treatment targets are discussed. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.
血脂异常，尤其是血清胆固醇水平升高，与心血管疾病存在因果关系。甘油三酯的具体作用长期以来一直存在争议。在本文中，我们将探讨血清甘油三酯在心血管疾病风险方面的作用。首先，描述甘油三酯的（病理）生理学，包括定义以及高甘油三酯血症的主要和次要病因的简要概述。此外，我们将概述已发表的有关高甘油三酯血症和心血管疾病的流行病学研究，以支持富含甘油三酯的脂蛋白是一个独立相关风险因素的观点。最后，讨论治疗策略和治疗目标。本文是名为“甘油三酯代谢与疾病”的特刊的一部分。
