Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Obesity (Silver Spring). 2012 Jan;20(1):200-5. doi: 10.1038/oby.2011.318. Epub 2011 Oct 20.
Recent studies suggest a possible link between post-traumatic stress disorder (PTSD) and obesity risk, which would have implications for the development of obesity-related diseases in this population. The present study examined the association between PTSD and obesity and whether this association differed by sex in a representative sample of the US population. A secondary objective was to determine whether the association between PTSD and obesity was mediated by binge eating disorder (BED). Data were from the Collaborative Psychiatric Epidemiology Surveys (CPES), which comprises three nationally representative cross-sectional surveys that were conducted between 2001 and 2003. Logistic regression analyses weighted to represent the general US adult population were performed. In the total sample of 20,013 participants, rates of obesity were 24.1% for persons without a lifetime history of PTSD and 32.6% among persons with PTSD in the past year. Adjusting for socio-demographic characteristics, depression, substance and alcohol abuse/dependence, and psychotropic medication status, past year PTSD was associated with greater likelihood of obesity (odds ratio (OR) = 1.51; 95% confidence interval (CI) = 1.18, 1.95), with no differences by gender. BED did not statistically mediate the relationship between PTSD and obesity. The present study provides support for a link between PTSD and obesity. Findings further existing literature by indicating that the association is consistent across sexes and is not statistically mediated by BED.
最近的研究表明,创伤后应激障碍(PTSD)与肥胖风险之间可能存在关联,这将对该人群中肥胖相关疾病的发展产生影响。本研究在具有代表性的美国人群样本中,调查了 PTSD 与肥胖之间的关联,以及这种关联是否因性别而异。次要目的是确定 PTSD 和肥胖之间的关联是否通过暴食障碍(BED)来介导。数据来自合作精神流行病学调查(CPES),该调查由三个在 2001 年至 2003 年之间进行的全国代表性横断面调查组成。进行了加权以代表一般美国成年人口的逻辑回归分析。在 20133 名参与者的总样本中,没有终生 PTSD 史的人的肥胖率为 24.1%,而过去一年患有 PTSD 的人的肥胖率为 32.6%。调整社会人口统计学特征、抑郁、物质和酒精滥用/依赖以及精神药物状况后,过去一年的 PTSD 与肥胖的可能性更大相关(优势比(OR)=1.51;95%置信区间(CI)=1.18,1.95),性别之间无差异。BED 并没有在 PTSD 和肥胖之间的关系中起到统计学上的中介作用。本研究为 PTSD 和肥胖之间的联系提供了支持。研究结果进一步证实了现有文献,表明这种关联在性别之间是一致的,并且不受 BED 的统计学中介。