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1
Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.用梅毒螺旋体内鞭毛进行免疫接种可改变实验性兔梅毒的病程。
Infect Immun. 1990 Sep;58(9):3158-61. doi: 10.1128/iai.58.9.3158-3161.1990.
2
Treponemicidal antibody measured by the "washed-killing" assay correlates with immunity in experimental rabbit syphilis.通过“洗涤杀伤”试验测定的杀梅毒螺旋体抗体与实验性兔梅毒的免疫力相关。
Sex Transm Dis. 1995 Jan-Feb;22(1):31-8. doi: 10.1097/00007435-199501000-00006.
3
The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum.噬菌性密螺旋体生物变种赖特株与梅毒螺旋体 Nichols 株内鞭毛之间的抗原相互关系。I. 交叉反应性内鞭毛抗体对梅毒螺旋体的杀梅毒螺旋体活性。
J Immunol. 1986 Nov 1;137(9):2973-9.
4
Non-pathogenic Borrelia burgdorferi expressing Treponema pallidum TprK and Tp0435 antigens as a novel approach to evaluate syphilis vaccine candidates.表达梅毒密螺旋体 TprK 和 Tp0435 抗原的无致病性伯氏疏螺旋体作为评估梅毒候选疫苗的新方法。
Vaccine. 2019 Mar 22;37(13):1807-1818. doi: 10.1016/j.vaccine.2019.02.022. Epub 2019 Feb 20.
5
Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.从梅毒密螺旋体生物变种赖特氏菌纯化的鞭毛不能诱导家兔产生针对实验性梅毒的保护性免疫。
Sex Transm Dis. 1985 Jul-Sep;12(3):124-7. doi: 10.1097/00007435-198507000-00006.
6
Immunization of rabbits with recombinant Treponema pallidum surface antigen 4D alters the course of experimental syphilis.用重组梅毒螺旋体表面抗原4D免疫兔子可改变实验性梅毒的病程。
J Immunol. 1988 Apr 1;140(7):2415-21.
7
Immunization with nontreponemal antigen alters the course of experimental syphilis in the rabbit model.用非梅毒螺旋体抗原免疫可改变兔实验性梅毒的病程。
Int Immunopharmacol. 2020 Dec;89(Pt B):107100. doi: 10.1016/j.intimp.2020.107100. Epub 2020 Oct 19.
8
Immunization with Treponema pallidum outer membrane vesicles induces high-titer complement-dependent treponemicidal activity and aggregation of T. pallidum rare outer membrane proteins (TROMPs).用梅毒螺旋体外膜囊泡进行免疫接种可诱导产生高滴度的补体依赖性杀梅毒螺旋体活性以及梅毒螺旋体稀有外膜蛋白（TROMPs）的聚集。
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9
Immunization of rabbits with Spirochaeta aurantia does not induce resistance to Treponema pallidum.用橙色螺旋体免疫兔子不会诱导产生对梅毒螺旋体的抵抗力。
Sex Transm Dis. 1984 Jan-Mar;11(1):1-5. doi: 10.1097/00007435-198401000-00001.
10
Complement activation limits the rate of in vitro treponemicidal activity and correlates with antibody-mediated aggregation of Treponema pallidum rare outer membrane protein.补体激活限制了体外杀梅毒螺旋体活性的速率，并与抗体介导的梅毒螺旋体稀有外膜蛋白聚集相关。
J Immunol. 1990 Mar 1;144(5):1914-21.

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6
A defined syphilis vaccine candidate inhibits dissemination of Treponema pallidum subspecies pallidum.一种确定的梅毒疫苗候选物可抑制苍白密螺旋体亚种的传播。
Nat Commun. 2017 Feb 1;8:14273. doi: 10.1038/ncomms14273.
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Quantitative assessment of protection in experimental syphilis.实验性梅毒中保护作用的定量评估。
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A monoclonal antibody that conveys in vitro killing and partial protection in experimental syphilis binds a phosphorylcholine surface epitope of Treponema pallidum.一种在实验性梅毒中具有体外杀伤作用和部分保护作用的单克隆抗体可结合梅毒螺旋体的磷酸胆碱表面表位。
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本文引用的文献

1
STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM.实验性梅毒免疫研究。I. 用赖特蛋白抗原免疫并接种毒力梅毒螺旋体的家兔的免疫反应
Br J Vener Dis. 1963 Sep;39(3):195-8. doi: 10.1136/sti.39.3.195.
2
Immunogenic properties of the protein component of Treponema pallidum.梅毒螺旋体蛋白质成分的免疫原性特性。
Br J Vener Dis. 1969 Dec;45(4):299-304. doi: 10.1136/sti.45.4.299.
3
Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation.实验性梅毒的免疫。VI. 用经γ射线照射减毒的梅毒螺旋体Nichols株成功对兔子进行疫苗接种。
J Immunol. 1973 May;110(5):1206-15.
4
Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.从梅毒密螺旋体生物变种赖特氏菌纯化的鞭毛不能诱导家兔产生针对实验性梅毒的保护性免疫。
Sex Transm Dis. 1985 Jul-Sep;12(3):124-7. doi: 10.1097/00007435-198507000-00006.
5
The antigenic interrelationship between the endoflagella of Treponema phagedenis biotype Reiter and Treponema pallidum Nichols strain. I. Treponemicidal activity of cross-reactive endoflagellar antibodies against T. pallidum.噬菌性密螺旋体生物变种赖特株与梅毒螺旋体 Nichols 株内鞭毛之间的抗原相互关系。I. 交叉反应性内鞭毛抗体对梅毒螺旋体的杀梅毒螺旋体活性。
J Immunol. 1986 Nov 1;137(9):2973-9.
6
Correlation of treponemicidal activity in normal human serum with the presence of IgG antibody directed against polypeptides of Treponema phagedenis biotype Reiter and Treponema pallidum, Nichols strain.正常人血清中杀梅毒螺旋体活性与针对嗜菌体梅毒亚种赖氏生物型和梅毒螺旋体Nichols株多肽的IgG抗体存在情况的相关性。
J Immunol. 1986 Sep 15;137(6):2031-6.
7
Analysis of sheath and core structures of the axial filament of Treponema pallidum.
J Gen Microbiol. 1987 Jun;133(6):1397-407. doi: 10.1099/00221287-133-6-1397.
8
Isolation and characterization of recombinant Escherichia coli clones secreting a 24-kilodalton antigen of Treponema pallidum.分泌梅毒螺旋体24千道尔顿抗原的重组大肠杆菌克隆的分离与鉴定
Infect Immun. 1988 May;56(5):1135-43. doi: 10.1128/iai.56.5.1135-1143.1988.
9
Demonstration of rare protein in the outer membrane of Treponema pallidum subsp. pallidum by freeze-fracture analysis.通过冷冻断裂分析显示梅毒螺旋体苍白亚种外膜中的稀有蛋白。
J Bacteriol. 1989 Sep;171(9):5005-11. doi: 10.1128/jb.171.9.5005-5011.1989.
10
Cloning and sequencing of a Treponema pallidum gene encoding a 31.3-kilodalton endoflagellar subunit (FlaB2).编码31.3千道尔顿内鞭毛亚基（FlaB2）的梅毒螺旋体基因的克隆与测序
Infect Immun. 1989 Jul;57(7):2166-72. doi: 10.1128/iai.57.7.2166-2172.1989.

用梅毒螺旋体内鞭毛进行免疫接种可改变实验性兔梅毒的病程。

Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.

作者信息

Champion C I, Miller J N, Borenstein L A, Lovett M A, Blanco D R

机构信息

Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.

出版信息

Infect Immun. 1990 Sep;58(9):3158-61. doi: 10.1128/iai.58.9.3158-3161.1990.

DOI:10.1128/iai.58.9.3158-3161.1990
PMID:2201648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC313628/
Abstract

Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.

摘要

在32周的时间里，给兔子总共注射450微克纯化的梅毒螺旋体轴丝。通过酶联免疫吸附测定法测量，免疫兔子的血清中抗轴丝抗体滴度比感染免疫兔子和二期疾病患者血清的滴度高五倍。通过体外固定化测量，所有免疫动物的血清都具有补体依赖性杀梅毒螺旋体活性。用强毒梅毒螺旋体攻击的免疫动物没有免受症状性感染，但病变发展过程有所改变。