用梅毒螺旋体内鞭毛进行免疫接种可改变实验性兔梅毒的病程。
Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.
作者信息
Champion C I, Miller J N, Borenstein L A, Lovett M A, Blanco D R
机构信息
Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.
出版信息
Infect Immun. 1990 Sep;58(9):3158-61. doi: 10.1128/iai.58.9.3158-3161.1990.
Abstract
Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.
摘要
在32周的时间里，给兔子总共注射450微克纯化的梅毒螺旋体轴丝。通过酶联免疫吸附测定法测量，免疫兔子的血清中抗轴丝抗体滴度比感染免疫兔子和二期疾病患者血清的滴度高五倍。通过体外固定化测量，所有免疫动物的血清都具有补体依赖性杀梅毒螺旋体活性。用强毒梅毒螺旋体攻击的免疫动物没有免受症状性感染，但病变发展过程有所改变。
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Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.从梅毒密螺旋体生物变种赖特氏菌纯化的鞭毛不能诱导家兔产生针对实验性梅毒的保护性免疫。
Sex Transm Dis. 1985 Jul-Sep;12(3):124-7. doi: 10.1097/00007435-198507000-00006.
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J Immunol. 1986 Nov 1;137(9):2973-9.
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Correlation of treponemicidal activity in normal human serum with the presence of IgG antibody directed against polypeptides of Treponema phagedenis biotype Reiter and Treponema pallidum, Nichols strain.正常人血清中杀梅毒螺旋体活性与针对嗜菌体梅毒亚种赖氏生物型和梅毒螺旋体Nichols株多肽的IgG抗体存在情况的相关性。
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