用梅毒螺旋体内鞭毛进行免疫接种可改变实验性兔梅毒的病程。
Immunization with Treponema pallidum endoflagella alters the course of experimental rabbit syphilis.
作者信息
Champion C I, Miller J N, Borenstein L A, Lovett M A, Blanco D R
机构信息
Department of Microbiology, School of Medicine, University of California, Los Angeles 90024.
出版信息
Infect Immun. 1990 Sep;58(9):3158-61. doi: 10.1128/iai.58.9.3158-3161.1990.
Abstract
Rabbits were immunized over a 32-week period with a total of 450 micrograms of purified Treponema pallidum endoflagella. As measured by enzyme-linked immunosorbent assay, sera from immunized rabbits had antiendoflagellar antibody titers that were fivefold greater than titers of sera from infected immune rabbits and patients with secondary disease. Sera from all immunized animals possessed complement-dependent treponemicidal activity as measured by in vitro immobilization. Immunized animals challenged with virulent T. pallidum were not protected from symptomatic infection but showed an altered course of lesion development.
摘要
在32周的时间里，给兔子总共注射450微克纯化的梅毒螺旋体轴丝。通过酶联免疫吸附测定法测量，免疫兔子的血清中抗轴丝抗体滴度比感染免疫兔子和二期疾病患者血清的滴度高五倍。通过体外固定化测量，所有免疫动物的血清都具有补体依赖性杀梅毒螺旋体活性。用强毒梅毒螺旋体攻击的免疫动物没有免受症状性感染，但病变发展过程有所改变。
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本文引用的文献
1
STUDIES ON IMMUNITY IN EXPERIMENTAL SYPHILIS. I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM.
Br J Vener Dis. 1963 Sep;39(3):195-8. doi: 10.1136/sti.39.3.195.
2
Immunogenic properties of the protein component of Treponema pallidum.
Br J Vener Dis. 1969 Dec;45(4):299-304. doi: 10.1136/sti.45.4.299.
3
4
Purified flagella from Treponema phagedenis biotype Reiter does not induce protective immunity against experimental syphilis in rabbits.
Sex Transm Dis. 1985 Jul-Sep;12(3):124-7. doi: 10.1097/00007435-198507000-00006.
5
6
7
Analysis of sheath and core structures of the axial filament of Treponema pallidum.
J Gen Microbiol. 1987 Jun;133(6):1397-407. doi: 10.1099/00221287-133-6-1397.
8
Isolation and characterization of recombinant Escherichia coli clones secreting a 24-kilodalton antigen of Treponema pallidum.
Infect Immun. 1988 May;56(5):1135-43. doi: 10.1128/iai.56.5.1135-1143.1988.
9
Demonstration of rare protein in the outer membrane of Treponema pallidum subsp. pallidum by freeze-fracture analysis.
J Bacteriol. 1989 Sep;171(9):5005-11. doi: 10.1128/jb.171.9.5005-5011.1989.
10
Cloning and sequencing of a Treponema pallidum gene encoding a 31.3-kilodalton endoflagellar subunit (FlaB2).
Infect Immun. 1989 Jul;57(7):2166-72. doi: 10.1128/iai.57.7.2166-2172.1989.
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