Seddon J M, Sahagian C R, Glynn R J, Sperduto R D, Gragoudas E S
Massachusetts Eye and Ear Infirmary, Epidemiology Unit, Boston 02114.
Invest Ophthalmol Vis Sci. 1990 Aug;31(8):1592-8.
A system for classification of iris color based on standard photographs, developed for use in a multicenter study, is described. Categories of iris color are distinguished based on predominant color (blue, gray, green, light brown, or brown) and the amount of brown or yellow pigment present in the iris. Two trained readers independently graded 339 iris photographs; discrepancies in grades were adjudicated. Measures of interobserver reliability were 0.76 by kappa for exact agreement and 0.97 for weighted kappa. The distribution of iris color grades demonstrates that the system achieved an appropriate level of detail within the authors' study population, which included patients with various racial backgrounds from five urban clinical centers. This simple, reliable classification system for iris color is offered for use in clinical research.
本文描述了一种基于标准照片的虹膜颜色分类系统，该系统是为多中心研究而开发的。虹膜颜色类别根据主要颜色（蓝色、灰色、绿色、浅棕色或棕色）以及虹膜中棕色或黄色色素的含量来区分。两名经过培训的阅片者独立对339张虹膜照片进行分级；对分级差异进行裁决。观察者间可靠性的测量结果显示，完全一致时kappa值为0.76，加权kappa值为0.97。虹膜颜色分级的分布表明，该系统在作者的研究人群中实现了适当的细节水平，该研究人群包括来自五个城市临床中心的具有不同种族背景的患者。这种简单、可靠的虹膜颜色分类系统可供临床研究使用。
