Ertugrul Bulent, Kirdar Sevin, Ersoy Ozlem Saylak, Ture Mevlut, Erol Nermin, Ozturk Barcin, Sakarya Serhan
Department of Infectious Diseases and Clinical Microbiology, University of Adnan Menderes School of Medicine, 09100 Aydin, Turkey.
Scand J Infect Dis. 2012 Apr;44(4):276-81. doi: 10.3109/00365548.2011.621445. Epub 2011 Oct 22.
In Turkey, Crimean-Congo haemorrhagic fever (CCHF) is seen particularly in the north-eastern part of Anatolia. Aydin was thought to be a non-endemic area, however the first case was reported from Aydin in 2006 and a total of 39 cases were reported between 2006 and 2010.
Four hundred and twenty-nine volunteers from 3 endemic regions of Aydin were enrolled in this study. We determined the IgG seropositivity against the virus by enzyme-linked immunosorbent assay (ELISA) method.
IgG seropositivity in the study group was found to be 19.6% (n = 84). Chi-squared automatic interaction detector (CHAID) analysis was performed and a significant relationship between IgG seropositivity and tick-bite was found. The IgG seropositivity rate was 13% in cases without a history of tick-bite, while it was 41.1% in those with a tick-bite history (p < 0.001). In cases without a history of tick-bite (n = 339), the most important factor related to seropositivity was cattle-dealing. The seropositivity rate was higher in women than in men in the group dealing with cattle without a history of tick-bite (p = 0.013). In cases with a tick-bite history, the most important factor related to IgG seropositivity was age; the rate was 81% in cases younger than 34 y old, while it was 29% in cases older than 34 y.
This study indicates that people suffering from the disease did not ask for any professional healthcare or that the healthcare providers could not diagnose these cases.
在土耳其，克里米亚-刚果出血热（CCHF）尤其在安纳托利亚东北部地区出现。艾登曾被认为是一个非疫区，然而2006年艾登报告了首例病例，2006年至2010年间共报告了39例病例。
本研究招募了来自艾登3个疫区的429名志愿者。我们通过酶联免疫吸附测定（ELISA）方法测定了针对该病毒的IgG血清阳性率。
研究组中IgG血清阳性率为19.6%（n = 84）。进行了卡方自动相互作用检测器（CHAID）分析，发现IgG血清阳性率与蜱叮咬之间存在显著关系。无蜱叮咬史的病例中IgG血清阳性率为13%，而有蜱叮咬史的病例中该率为41.1%（p < 0.001）。在无蜱叮咬史的病例（n = 339）中，与血清阳性相关的最重要因素是从事牲畜交易。在无蜱叮咬史的从事牲畜交易的人群中，女性的血清阳性率高于男性（p = 0.013）。在有蜱叮咬史的病例中，与IgG血清阳性相关的最重要因素是年龄；34岁以下的病例中该率为81%，而34岁以上的病例中该率为29%。
本研究表明，患病者未寻求任何专业医疗护理，或者医疗服务提供者无法诊断这些病例。
