Department of Mechanical Engineering and Materials Science, Washington University, St. Louis, Missouri 63130, USA.
Anal Chem. 2011 Dec 1;83(23):8953-8. doi: 10.1021/ac2016882. Epub 2011 Nov 3.
We report a novel surface enhanced Raman scattering (SERS) substrate platform based on a common filter paper adsorbed with plasmonic nanostructures that overcomes many of the challenges associated with existing SERS substrates. The paper-based design results in a substrate that combines all of the advantages of conventional rigid and planar SERS substrates in a dynamic flexible scaffolding format. In this paper, we discuss the fabrication, physical characterization, and SERS activity of our novel substrates using nonresonant analytes. The SERS substrate was found to be highly sensitive, robust, and amiable to several different environments and target analytes. It is also cost-efficient and demonstrates high sample collection efficiency and does not require complex fabrication methodologies. The paper substrate has high sensitivity (0.5 nM trans-1,2-bis(4-pyridyl)ethene (BPE)) and excellent reproducibility (~15% relative standard deviation (RSD)). The paper substrates demonstrated here establish a novel platform for integrating SERS with already existing analytical techniques such as chromatography and microfluidics, imparting chemical specificity to these techniques.
我们报告了一种基于带有等离子体纳米结构的普通滤纸的新型表面增强拉曼散射（SERS）基底平台，该平台克服了现有 SERS 基底所面临的许多挑战。基于纸张的设计使得基底结合了传统刚性和平面 SERS 基底的所有优点，形成了一种动态灵活的支架形式。在本文中，我们使用非共振分析物讨论了我们新型基底的制造、物理特性和 SERS 活性。该 SERS 基底被发现具有高度的灵敏度、稳健性，并且对多种不同的环境和目标分析物具有亲和力。它还具有成本效益，并且表现出高的样品收集效率，不需要复杂的制造方法。纸基底具有高灵敏度（0.5 nM 反式-1,2-双（4-吡啶基）乙烯（BPE））和出色的重现性（约 15%相对标准偏差（RSD））。本文中展示的纸基底为将 SERS 与已经存在的分析技术（如色谱和微流控）相结合建立了一个新的平台，为这些技术赋予了化学特异性。
