Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143, USA.
Neuron. 2011 Oct 20;72(2):191-3. doi: 10.1016/j.neuron.2011.10.003.
Cleavage plane orientation has been thought to govern the fate of neural stem cell progeny, but supporting evidence in the neocortex has been sparse. A new study by Postiglione et al. in this issue of Neuron shows that mouse Inscuteable-mediated control of cleavage plane orientation regulates the output of neural progenitor cells.
分裂面方向被认为控制着神经干细胞后代的命运,但在新皮层中支持这一观点的证据很少。波斯特利昂内等人在本期《神经元》杂志上的一项新研究表明,小鼠 Inscuteable 介导的分裂面方向控制调节神经祖细胞的输出。