*Clinical Lecturer, Medical Oncology, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
Obstet Gynecol Surv. 2011 Aug;66(8):507-14. doi: 10.1097/OGX.0b013e318234ede9.
Malignant ovarian germ cell tumors are rare, highly curable cancers of young women. The majority of patients can be cured with either fertility-preserving surgery alone or a combination of surgery and chemotherapy. Relapses occur in 10% to 20% of patients, and the significant proportion of them can be salvaged with chemotherapy. There is no evidence that treatment for malignant ovarian germ cell tumors will adversely affect menstrual or reproductive functions, increase future pregnancy loss, or increase the risk of congenital malformations of the fetus. Late effects, such as secondary leukemia, from chemotherapy are reported but rare.
Obstetricians & Gynecologists and Family Physicians.
After completing this CME activity, physicians should be better able to diagnose ovarian germ cell tumors, outline management of malignant ovarian germ cell tumors, and understand the impact of treatment on fertility and late effects.
恶性卵巢生殖细胞肿瘤是一种罕见的、高度可治愈的年轻女性癌症。大多数患者可以通过保留生育能力的手术单独或手术和化疗联合治愈。10%至 20%的患者会复发，其中很大一部分可以通过化疗挽救。没有证据表明恶性卵巢生殖细胞肿瘤的治疗会对月经或生殖功能产生不利影响，增加未来流产的风险，或增加胎儿先天畸形的风险。据报道，化疗后会出现继发性白血病等晚期影响，但很少见。
妇产科医生和家庭医生。
完成这个 CME 活动后，医生应该能够更好地诊断卵巢生殖细胞肿瘤，概述恶性卵巢生殖细胞肿瘤的治疗方法，并了解治疗对生育和晚期影响。
